Evidence map›Paper›PMID 36036155›Full record

ArticleJournal of enzyme inhibition and medicinal chemistry2022

New pyrazolylpyrazoline derivatives as dual acting antimalarial-antileishamanial agents: synthesis, biological evaluation and molecular modelling simulations.

Adnan A Bekhit, Eskedar T Lodebo, Ariaya Hymete, Hanan M Ragab, Salma A Bekhit, Kikuko Amagase, Afnan Batubara, Mohammed A S Abourehab, Alaa El-Din A Bekhit, Tamer M Ibrahim

Open access · goldAbstract read
In one paragraph

Article in Journal of enzyme inhibition and medicinal chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 7 institutions in 6 countries.

Adnan A BekhitDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.ORCID 0000-0003-3865-0677
Eskedar T LodeboDepartment of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
Ariaya HymeteDepartment of Pharmaceutical Chemistry and Pharmacognosy, School of Pharmacy, Addis Ababa University, Addis Ababa, Ethiopia.
Hanan M RagabDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, Egypt.
Salma A BekhitHigh Institute of Public Health, Alexandria University, Alexandria, Egypt.
Kikuko AmagaseLaboratory of Pharmacology & Pharmacotherapeutics, College of Pharmaceutical Sciences, Ritsumeikan University, Kusatsu, Japan.
Afnan BatubaraDepartment of Pharmaceutical Chemistry, College of Pharmacy, Umm Al-Qurra University, Makkah, Saudi Arabia.
Mohammed A S AbourehabDepartment of Pharmaceutics, College of Pharmacy, Umm Al-Qura University, Makkah, Saudi Arabia.
Alaa El-Din A BekhitFood Sciences, University of Otago, Dunedin, New Zealand.ORCID 0000-0003-2569-8620
Tamer M IbrahimDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Kafrelsheikh University, Kafr El-Sheikh, Egypt.ORCID 0000-0003-1016-8950
University of Bahrain · BHRitsumeikan University · JPUmm al-Qura University · SAAddis Ababa University · ETAlexandria University · EGKafrelsheikh University · EGKotebe University of Education · ET

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Promising inhibitory activities of the parasite multiplication were obtained upon evaluation of

Indexed as

AntimalarialsAntiprotozoal AgentsFolic Acid AntagonistsLeishmaniaAnimalsChloroquineMiceMolecular Dynamics SimulationPlasmodium bergheiPlasmodium falciparumAntimalarialsAntiprotozoal AgentsChloroquineFolic Acid Antagonistsantifolate mechanismantileishmanial evaluationantimalarial evaluationmolecular dockingmolecular dynamicsPyrazoline derivatives

Identifiers

PMID36036155
PMCPMC9427035
OpenAlexW4293761446

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.