ArticleFrontiers in cardiovascular medicine2022
Association of Early and Supernormal Vascular Aging categories with cardiovascular disease in the Chinese population.
Article in Frontiers in cardiovascular medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Comparison of Vascular Aging Models on the Basis of Different Vascular Indicators for Cardiovascular Events Prediction: A Chinese Community-Based Cohort Study.Journal of the American Heart Association · 2026Article
- The modifying effect of chronological age on the predictive value of vascular aging indicators for the long-term cardiovascular events risk.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Association between serum 25-hydroxyvitamin D levels and Early Vascular Aging in young and middle-aged adults.PloS one · 2026Article
- Comparison between vascular age based on brachial-ankle pulse wave velocity or carotid-femoral pulse wave velocity.Hypertension research : official journal of the Japanese Society of Hypertension · 2025Article
- Association of Vascular Aging Phenotypes with Adverse Clinical Outcomes in the Chinese Population: A Multicentre Study.Clinical interventions in aging · 2025Article
- Early vascular aging determined by brachial-ankle pulse wave velocity and its impact on ischemic stroke outcome: a retrospective observational study.Scientific reports · 2024Observational
- Atrial Fibrillation and Early Vascular Aging: Clinical Implications, Methodology Issues and Open Questions-A Review from the VascAgeNet COST Action.Journal of clinical medicine · 2024Review
- Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases.Frontiers in nutrition · 2023Review
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13 authors.
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Abstract
Background: Early Vascular Aging and Supernormal Vascular Aging are two extreme phenotypes of vascular aging, and people in the two categories demonstrate distinct clinical characteristics and cardiovascular prognosis. However, the clinical implication of vascular aging categories in the Asian or Chinese population has not been investigated. We aimed to investigate the association between vascular aging categories and cardiovascular events in a Chinese cohort. Methods: We explored the association of vascular aging categories with incident cardiovascular disease in a community cohort in Shanghai, China, which included 10,375 participants following up for 4.5 years. Vascular age was predicted by a multivariable linear regression model including classical risk factors and brachial-ankle pulse wave velocity. Early and Supernormal vascular aging groups were defined by 10% and 90% percentiles of Δ-age, which was calculated as chronological minus vascular age. Results: We found that cardiovascular risk significantly increased in Early [hazard ratio (HR), 1.597 (95% CI, 1.043-2.445)] and decreased in Supernormal [HR, 0.729 (95% CI, 0.539-0.986)] vascular aging individuals, comparing with normal vascular aging subjects. The associations were independent of the Framingham risk score. Early vascular aging individuals also showed an elevated risk of total mortality [HR, 2.614 (95% CI, 1.302-5.249)]. Further, the associations of vascular aging categories with cardiovascular risk were much stronger in females than in males. Vascular aging categories with different cutoff levels expressed as percentiles (10th, 20th, and 25th) of Δ-age showed similar associations with cardiovascular risk. Conclusions: In conclusion, the vascular aging categories could identify people with different levels of cardiovascular risk in the Chinese population, particularly in women.
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