ReviewFrontiers in physiology2022
Time Domains of Hypoxia Responses and -Omics Insights.
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Review in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16citing papers in PubMed
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Who cites it
16 citing papers in PubMed.
- High-Altitude Hypoxia Injury: Systemic Mechanisms and Intervention Strategies on Immune and Inflammatory Responses.Antioxidants (Basel, Switzerland) · 2025Review
- Hypoxia and Tissue Regeneration: Adaptive Mechanisms and Therapeutic Opportunities.International journal of molecular sciences · 2025Review
- Genetic adaptations shaping survival, pregnancy, and life at high altitude and sea level.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Review
- AdaptiveiScience · 2025Article
- Hypoxia's Impact on Hippocampal Functional Connectivity: Insights from Resting-State fMRI Studies.Brain sciences · 2025Review
- Improved oxygen saturation and acclimatization with bacteriotherapy at high altitude.iScience · 2025Article
- Convergent evolution of complex adaptive traits modulates angiogenesis in high-altitude Andean and Himalayan human populations.Communications biology · 2025Article
- Non-histone lactylation: unveiling its functional significance.Frontiers in cell and developmental biology · 2025Review
- Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers.Frontiers in molecular biosciences · 2025Review
- FunctionalScience advances · 2024Article
- Hallmarks of aging: middle-aging hypovascularity, tissue perfusion and nitric oxide perspective on healthspan.Frontiers in aging · 2024Article
- Tibetans exhibit lower hemoglobin concentration and decreased heart response to hypoxia during poikilocapnia at intermediate altitude relative to Han Chinese.Frontiers in physiology · 2024Article
- Manipulative neuroparasites: uncovering the intricacies of neurological host control.Archives of microbiology · 2023Review
- Consistent differences in brain structure and functional connectivity in high-altitude native Tibetans and immigrants.Brain imaging and behavior · 2023Article
- Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis.Frontiers in aging · 2023Article
- EPAS1/HIF-2α: a key regulator for chronic hypoxia across species.The Journal of physiology · 2022Article
Corrections and comments
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Authors and funding
40 authors.
James J YuDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Amy L NonDepartment of Anthropology, Division of Social Sciences, University of California, San Diego, La Jolla, CA, United States.
Erica C HeinrichDivision of Biomedical Sciences, School of Medicine, University of California, Riverside, CA, United States.
Wanjun GuDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Joe AlcockDepartment of Emergency Medicine, University of New Mexico, Albuquerque, MX, United States.
Esteban A MoyaDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Elijah S LawrenceDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Michael S TiftDepartment of Biology and Marine Biology, College of Arts and Sciences, University of North Carolina Wilmington, Wilmington, NC, United States.
Katie A O'BrienDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Jay F StorzSchool of Biological Sciences, College of Arts and Sciences, University of Nebraska-Lincoln, Lincoln, IL, United States.
Anthony V SignoreSchool of Biological Sciences, College of Arts and Sciences, University of Nebraska-Lincoln, Lincoln, IL, United States.
Jane I KhudyakovDepartment of Biological Sciences, University of the Pacific, Stockton, CA, United States.
William K MilsomDepartment of Zoology, Vancouver, BC, Canada.
Sean M WilsonLawrence D. Longo, MD Center for Perinatal Biology, Loma Linda, CA, United States.
Cynthia M BeallDepartment of Anthropology, Cleveland, OH, United States.
Francisco C VillafuerteLaboratorio de Fisiología Comparada/Fisiología del Transporte de Oxígeno, Lima, Peru.
Tsering StobdanDepartment of Pediatrics, San Diego, CA, United States.
Colleen G JulianSchool of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Lorna G MooreDivision of Reproductive Sciences, Department of Obstetrics and Gynecology, Aurora, CO, United States.
Mark M FusterDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Jennifer A StokesDepartment of Kinesiology, Southwestern University, Georgetown, TX, United States.
Richard MilnerSan Diego Biomedical Research Institute, San Diego, CA, United States.
John B WestDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Jiao ZhangDepartment of Medicine, UC San Diego School of Medicine, San Diego, CA, United States.
John Y ShyyDepartment of Medicine, UC San Diego School of Medicine, San Diego, CA, United States.
Ainash ChildebayevaDepartment of Archaeogenetics, Max Planck Institute for Evolutionary Anthropology, Leipzig, Germany.
José Pablo Vázquez-MedinaDepartment of Integrative Biology, College of Letters and Science, University of California, Berkeley, Berkeley, CA, United States.
Luu V PhamDivision of Pulmonary and Critical Care Medicine, Department of Medicine, School of Medicine, Johns Hopkins Medicine, Baltimore, MD, United States.
Omar A MesarwiDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
James E HallDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Zachary A ChevironDivision of Biological Sciences, College of Humanities and Sciences, University of Montana, Missoula, MT, United States.
Jeremy SiekerDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Arlin B BloodDepartment of Pediatrics Division of Neonatology, School of Medicine, Loma Linda University, Loma Linda, CA, United States.
Jason X YuanDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Graham R ScottDepartment of Pediatrics Division of Neonatology, School of Medicine, Loma Linda University, Loma Linda, CA, United States.
Brinda K RanaMoores Cancer Center, UC San Diego, La Jolla, CA, United States.
Paul J PonganisCenter for Marine Biotechnology and Biomedicine, La Jolla, CA, United States.
Atul MalhotraDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Frank L PowellDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Tatum S SimonsonDivision of Pulmonary, Critical Care and Sleep Medicine, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, United States.
Funding
Uterine Vascular Adaptation to Pregnancy and Chronic HypoxiaP01HD083132 · NICHD · LOMA LINDA UNIVERSITY · PI DUCSAY, CHARLES A · 2016 to 2020
$6.3MMutational Pleiotropy, Epistasis, and the Adaptive Evolution of Hemoglobin FunctionR01HL087216 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2008 to 2021
$4.5MRespiratory and genomic contributions to adaptive/maladaptive hypoxia responsesR01HL145470 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2019 to 2023
$2.4MGenomic and physiological mechanisms of hypoxia adaptation in high-altitude miceR01HL159061 · NHLBI · UNIVERSITY OF NEBRASKA LINCOLN · PI STORZ, JAY · 2022 to 2025
$1.9MHypoxia, HIF-1, and the progression of nonalcoholic fatty liver disease in obstructive sleep apneaK08HL143140 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MESARWI, OMAR · 2019 to 2023
$888kIntegrating physiology and genomics to reveal functional adaptation in high-altitK99HL118215 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SIMONSON, TATUM S · 2014 to 2014
$85kGlycocalyx Targeting and Augmenting Cellular Immunity in Lung CancerI01BX003688 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI FUSTER, MARK M · 2018 to 2025
–BLRD VA I01 BX003688NHLBI NIH HHS K08 HL143140NHLBI NIH HHS K99 HL118215NHLBI NIH HHS R01 HL087216NHLBI NIH HHS R01 HL145470NHLBI NIH HHS R01 HL159061NICHD NIH HHS P01 HD083132
Abstract
The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context of high-altitude exposure, cardiopulmonary disease, and sleep apnea), and how findings from each of these fields inform the other and lead to promising new directions in basic and clinical hypoxia research.
Indexed as
adaptationhigh altitudehypoxiaintegrative physiologyoxygen
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.