ArticleFrontiers in medicine2022
Inverse association between low-density lipoprotein cholesterol and bone mineral density in young- and middle-aged people: The NHANES 2011-2018.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Proprotein Convertase Subtilisin/Kexin Type 9 Inhibitors and the Risk of Fracture: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Calcified tissue international · 2023Pooled it
- Article
- Serum alpha-klotho levels associate with bone mineral density in chronic kidney disease patients from NHANES 2011 to 2016.Scientific reports · 2025Article
- The diagnostic value of the combined application of blood lipid metabolism markers and interleukin-6 in osteoporosis and osteopenia.Lipids in health and disease · 2025Article
- Nonlinear relationship between lumbar bone mineral density and high-density lipoprotein cholesterol in patients with type 2 diabetes.Frontiers in endocrinology · 2025Article
- Remnant cholesterol is associated with hip BMD and low bone mass in young and middle-aged men: a cross-sectional study.Journal of endocrinological investigation · 2024Article
- The association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and the risk of osteoporosis among U.S. adults: analysis of NHANES data.Lipids in health and disease · 2024Article
- TC and LDL-C are negatively correlated with bone mineral density in patients with osteoporosis.American journal of translational research · 2024Article
- Association between triglyceride-glucose index and bone mineral density in US adults: a cross sectional study.Journal of orthopaedic surgery and research · 2023Article
- Correlation between Blood Lipid Level and Osteoporosis in Older Adults with Type 2 Diabetes Mellitus-A Retrospective Study Based on Inpatients in Beijing, China.Biomolecules · 2023Article
- The association of lipid metabolism with bone metabolism and the role of human traits: a Mendelian randomization study.Frontiers in endocrinology · 2023Article
- The Paradoxical Association of Lipids with Survival and Walking Ability of Hip Fractures in Geriatric Patients After Surgery: A 1-Year Follow-Up Study.International journal of general medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors.
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Abstract
Objectives: Low-density lipoprotein cholesterol (LDL-C) plays an essential part in bone metabolism. However, the correlation between LDL-C levels and bone mineral density (BMD) is still controversial. This study aimed to explore the relationship between LDL-C levels and lumbar BMD in young- and middle-aged people. Methods: We conducted a cross-sectional study comprising 4,441 participants aged 20-59 from the National Health and Nutrition Examination Survey (NHANES). LDL-C levels and lumbar BMD were used as independent and dependent variables, respectively. We evaluated the correlation between LDL-C levels and lumbar BMD through a weighted multivariate linear regression model. We performed a subgroup analysis of the relationship between LDL-C levels and lumbar BMD based on age, gender, and body mass index (BMI). Results: After adjusting for confounding factors, LDL-C levels were negatively correlated with lumbar BMD. In subgroup analyses stratified by gender, this negative association was statistically significant in men and women. In the subgroup analysis stratified by age, a negative connection existed in people aged 30-49 years. In the subgroup analysis divided by BMI, there was an inverse correlation in overweight people (25 ≤ BMI < 30). Conclusions: Our research observed an inverse association between LDL-C levels and lumbar BMD in young- and middle-aged people, especially in people aged 30-49 years and who are overweight. Close monitoring of BMD and early intervention may be required for these people.
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