Evidence map›Paper›PMID 36035361›Full record

ReviewJHEP reports : innovation in hepatology2022

Hepatopulmonary syndrome.

Sarah Raevens, Maxine Boret, Michael B Fallon

Abstract readReview
In one paragraph

Review in JHEP reports : innovation in hepatology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. The Role of Nitric Oxide in Chronic Liver Disease: A Review.Journal of clinical and translational hepatology · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Observational
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah RaevensDepartment of Gastroenterology and Hepatology, Ghent University - Ghent University Hospital, Ghent, Belgium.
Maxine BoretDepartment of Gastroenterology and Hepatology, Ghent University - Ghent University Hospital, Ghent, Belgium.
Michael B FallonDepartment of Internal Medicine, University of Arizona College of Medicine, Phoenix, AZ, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatopulmonary syndrome (HPS) is a pulmonary vascular complication of liver disease, which adversely affects prognosis. The disease is characterised by intrapulmonary vascular dilatations and shunts, resulting in impaired gas exchange. A complex interaction between the liver, the gut and the lungs, predominately impacting pulmonary endothelial cells, immune cells and respiratory epithelial cells, is responsible for the development of typical pulmonary alterations seen in HPS. Liver transplantation is the only therapeutic option and generally reverses HPS. Since the implementation of the model for end-stage liver disease (MELD) standard exception policy, outcomes in patients with HPS have been significantly better than they were in the pre-MELD era. This review summarises current knowledge and highlights what's new regarding the diagnosis and management of HPS, and our understanding of pathogenesis based on experimental models and translational studies.

Indexed as

ABG, arterial blood gasAT2, alveolar type IIAV, arteriovenousCBDL, common bile duct ligationcirrhosisET-1, endothelin-1ETB, endothelin receptor BFEV1, forced expiratory volume in the first secondFVC, forced vital capacityHPS, hepatopulmonary syndromeIPVDs, intrapulmonary vascular dilatationsLT, liver transplantationMELD exceptionsNO, nitric oxideP(A-a)O2, alveolar-arterial oxygenation gradientPaO2, partial pressure of arterial oxygenPDGF, platelet-derived growth factorPIGF, placental growth factorportal hypertensionPVL, portal vein ligationSaO2, oxygen saturationSE, standard exceptionSP, surfactant proteinTAA, thio-acetamideTc-MAA, 99mTechnetium-labeled macroaggregated albuminTNFα, tumour necrosis factor alphaUNOS, United Network for Organ SharingVCAM1, vascular cellular adhesion molecule 1VEGF, vascular endothelial growth factorV/Q, ventilation-perfusionvWF, von Willebrand factor

Identifiers

PMID36035361
PMCPMC9403489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.