Evidence map›Paper›PMID 36035208›Full record

ArticleOxidative medicine and cellular longevity2022

Novel Diagnostic Biomarkers Related to Oxidative Stress and Macrophage Ferroptosis in Atherosclerosis.

Minhui Li, Siyuan Xin, Ruiyuan Gu, Lin Zheng, Jie Hu, Ruijing Zhang, Honglin Dong

Abstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Minhui LiSecond Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0003-3037-4620
Siyuan XinBaotou Medical College, Inner Mongolia, China.ORCID https://orcid.org/0000-0001-7058-5460
Ruiyuan GuSecond Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0001-5329-643X
Lin ZhengSecond Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0001-7771-5483
Jie HuSecond Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0003-3431-7156
Ruijing ZhangSecond Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0003-0697-2217
Honglin DongSecond Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.ORCID https://orcid.org/0000-0002-5924-7003

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Atherosclerosis (AS) is a chronic inflammatory disease, which has a complex interplay between altered immune metabolism and oxidative stress. Therefore, we aimed to determine the oxidative stress and immune-related biomarkers in AS. Differential gene expression analyses are based on the GSE100927 dataset in the Gene Expression Omnibus (GEO), and 389 oxidative stress (OS) genes are identified based on gene set enrichment analysis (GSEA). We identified 74 differentially expressed genes related to oxidative stress (DEOSGs). "CIBERSORT" and "WGCNA" R Packages were used to compare the differences in immune infiltration levels between AS and control samples. The DEOSGs (

Indexed as

AtherosclerosisFerroptosisBiomarkersComputational BiologyGene Expression ProfilingGene Regulatory NetworksHumansMacrophagesMatrix Metalloproteinase 9Oxidative StressBiomarkersMatrix Metalloproteinase 9

Identifiers

PMID36035208
PMCPMC9410850

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.