ArticleiScience2022
The amount of SARS-CoV-2 RNA in wastewater relates to the development of the pandemic and its burden on the health system.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Genetic insights into hepatitis E virus through environmental surveillance in Europe.One health (Amsterdam, Netherlands) · 2026Review
- Distinct distribution of HEV-3 subtypes across humans, animals, and environmental waters in Sweden.Emerging microbes & infections · 2025Article
- Characterization of Human Viral Diversity and Adenovirus Isolates in a Sewage Treatment Plant in Tianjin: Implications for Public Health and Advanced Monitoring.Food and environmental virology · 2025Article
- High prevalence of hepatitis E and rat hepatitis E viruses in wastewater in Gothenburg, Sweden.One health (Amsterdam, Netherlands) · 2024Article
- Dynamic SARS-CoV-2 surveillance model combining seroprevalence and wastewater concentrations for post-vaccine disease burden estimates.Communications medicine · 2024Article
- Infectivity of exhaled SARS-CoV-2 aerosols is sufficient to transmit covid-19 within minutes.Scientific reports · 2023Article
- Wastewater surveillance provides 10-days forecasting of COVID-19 hospitalizations superior to cases and test positivity: A prediction study.Infectious Disease Modelling · 2023Article
- Wastewater and seroprevalence for pandemic preparedness: variant analysis, vaccination effect, and hospitalization forecasting for SARS-CoV-2, in Jefferson County, Kentucky.medRxiv : the preprint server for health sciences · 2023Article
- Sampling Considerations for Wastewater Surveillance of Antibiotic Resistance in Fecal Bacteria.International journal of environmental research and public health · 2023Article
- Gastrointestinal Endoscopy in Patients with Coronavirus Disease 2019: Indications, Findings, and Safety.Gastroenterology clinics of North America · 2023Review
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Virus surveillance in wastewater can be a useful indicator of the development of the COVID-19 pandemic in communities. However, knowledge about how the amount of SARS-CoV-2 RNA in wastewater relates to different data on the burden on the health system is still limited. Herein, we monitored the amount of SARS-CoV-2 RNA and the spectrum of virus variants in weekly pooled wastewater samples for two years from mid-February 2020 and compared them with several clinical data. The two-year monitoring showed the weekly changes in the amount of viral RNA in wastewater preceded the hospital care needs for COVID-19 and the number of acute calls on adult acute respiratory distress by 1-2 weeks during the first three waves of COVID-19. Our study demonstrates that virus surveillance in wastewater can predict the development of a pandemic and its burden on the health system, regardless of society's test capacity and possibility of tracking infected cases.
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Registered trials
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