ReviewCureus2022
Predicting Amputation in Patients With Diabetic Foot Ulcers: A Systematic Review.
Review in Cureus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The incidence of lower extremity amputation and its associated risk factors in patients with diabetic foot ulcers: A meta-analysis.International wound journal · 2024Pooled it
- Effect of diabetic foot ulcers and other risk factors on the prevalence of lower extremity amputation: A meta-analysis.International wound journal · 2023Pooled it
- Navigating Treatment Pathways in Diabetic Foot Infection: A Practical Retrospective Analysis of Healing Predictors and the WIfI System.International wound journal · 2026Article
- Rationales for Antibiotic Treatment Versus Direct Surgical Resection in Various Strata of Diabetic Foot Osteomyelitis-Literature Review and Expert Opinions.Antibiotics (Basel, Switzerland) · 2026Article
- Activating the cellular scavenger: A bioactive hydrogel promotes diabetic wounds via plant exosome-like nanovesicles enhanced macrophage efferocytosis.Bioactive materials · 2026Article
- Comprehensive Management of Diabetic Foot Ulcers: Current Evidence and Practice.Journal of diabetes · 2026Review
- Association between controlling nutritional status (CONUT) score and amputation risk factors in T2DM patients with DFU.Frontiers in endocrinology · 2026Article
- Advanced strategies for the management of patients with diabetic foot ulcers: a comprehensive review.The Korean journal of internal medicine · 2026Review
- Predictive model and risk analysis for outcomes in diabetic foot ulcer using eXtreme Gradient Boosting algorithm and SHapley Additive exPlanation.World journal of diabetes · 2025Article
- Risk factors and rates of revision amputation following ischemic lower major limb amputations: A 10-year retrospective analysis.Joint diseases and related surgery · 2025Article
- Intact fish skin graft a new hope for the treatment of diabetic foot ulcers: A case report.World journal of diabetes · 2024Article
- Neutrophil Extracellular Traps (NETs) Are Associated with Type 2 Diabetes and Diabetic Foot Ulcer Related Amputation: A Prospective Cohort Study.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2024Article
- Association of remoteness and ethnicity with major amputation following minor amputation to treat diabetes-related foot disease.PloS one · 2024Article
- Epidemiological Insights into Diabetic Foot Amputation and its Correlates: A Provincial Study.Clinical medicine insights. Endocrinology and diabetes · 2024Article
- Risk factor analysis for diabetic foot ulcer-related amputation including Controlling Nutritional Status score and neutrophil-to-lymphocyte ratio.International wound journal · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Foot ulcers are a leading cause of morbidity in diabetics. One of the known complications of diabetic foot ulcers is lower limb amputation which makes it a major socioeconomic problem. Currently, there's a lack of knowledge on the predictors of amputations in diabetics with foot ulcers. We performed a systematic review of studies that identified risk factors of amputation in patients with diabetic foot ulcers. This systematic review aims to identify the predictors of amputation in order to optimize the management strategy and care plan. Medline database was searched and inclusion criteria were implemented for the selection of studies. The risk factors extracted were part of four categories: (i) history and physical examination, (ii) ulcer characteristics, (iii) lab results, and (iv) co-morbidities. The data extracted were in the form of odds ratios, 95% confidence intervals, and predictive values. The mean values with standard deviations of the included risk factors were recorded, and the incidence of risk factors among the amputation groups was identified or calculated when the data were sufficient. Seven articles were selected reporting on 3481 patients. This review identified peripheral arterial disease, neuropathy, high Wagner's grade, osteomyelitis, postprandial glucose level, white cell count, c-reactive protein, erythrocyte sedimentation rate, low hemoglobin, and albumin as the most significant predictors of amputation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.