Evidence map›Paper›PMID 36034972›Full record

ArticleMatter2022

Surfaces with instant and persistent antimicrobial efficacy against bacteria and SARS-CoV-2.

Abhishek Dhyani, Taylor Repetto, Dylan Bartikofsky, Carmen Mirabelli, Zhihe Gao, Sarah A Snyder, Catherine Snyder, Geeta Mehta, Christiane E Wobus, J Scott VanEpps and 1 more

Abstract read
In one paragraph

Article in Matter, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Abhishek DhyaniMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Taylor RepettoBiointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Dylan BartikofskyDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Carmen MirabelliDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
Zhihe GaoMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Sarah A SnyderBiointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Catherine SnyderBiointerfaces Institute, University of Michigan, Ann Arbor, MI 48109, USA.
Geeta MehtaMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Christiane E WobusDepartment of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA.
J Scott VanEppsMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.
Anish TutejaMacromolecular Science and Engineering, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Alexey I Nesvizhskii · 1988 to 2026
$178.2M
Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
CELLULAR AND MOLECULAR BIOLOGY AT MICHIGANT32GM007315 · NIGMS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PUTHENVEEDU, MANOJKUMAR A · 1985 to 2021
$12.8M
Antimicrobial mechanisms of action zinc oxide nanoparticlesK08AI128006 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI VANEPPS, J SCOTT · 2017 to 2020
$778k
NCATS NIH HHS UL1 TR002240NCI NIH HHS P30 CA046592NIAID NIH HHS K08 AI128006NIGMS NIH HHS T32 GM007315
6 · The paper itself

Abstract

Surfaces contaminated with bacteria and viruses contribute to the transmission of infectious diseases and pose a significant threat to global public health. Modern day disinfection either relies on fast-acting (>3-log reduction within a few minutes), yet impermanent, liquid-, vapor-, or radiation-based disinfection techniques, or long-lasting, but slower-acting, passive antimicrobial surfaces based on heavy metal surfaces, or metallic nanoparticles. There is currently no surface that provides instant and persistent antimicrobial efficacy against a broad spectrum of bacteria and viruses. In this work, we describe a class of extremely durable antimicrobial surfaces incorporating different plant secondary metabolites that are capable of rapid disinfection (>4-log reduction) of current and emerging pathogens within minutes, while maintaining persistent efficacy over several months and under significant environmental duress. We also show that these surfaces can be readily applied onto a variety of desired substrates or devices via simple application techniques such as spray, flow, or brush coating.

Indexed as

antimicrobialantiviralCOVID-19durablegram-negativegram-positiveinstant killlong-lastingpersistentSARS-COV-2

Identifiers

PMID36034972
PMCPMC9399129

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.