ArticleFrontiers in nutrition2022
Alleviating effects of pea peptide on oxidative stress injury induced by lead in PC12 cells
Article in Frontiers in nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Azilsartan as a novel anti-ferriptotic agent via the upregulation of the Nrf2/HO-1/SLC7A11/GPX4 axis and downregulation of inflammatory pathways in folic acid-induced acute kidney injury in male mice.Toxicology reports · 2026Article
- Pea Peptide Modulates Abnormal Aβ Production in PC12 Cells Induced by Lead Exposure.Plant foods for human nutrition (Dordrecht, Netherlands) · 2025Article
- Comparative Study of the Protective and Neurotrophic Effects of Neuronal and Glial Progenitor Cells-Derived Conditioned Media in a Model of Glutamate Toxicity In Vitro.Biomolecules · 2023Article
- Palmatine Protects PC12 Cells and Mice from Aβ25-35-Induced Oxidative Stress and Neuroinflammation via the Nrf2/HO-1 Pathway.Molecules (Basel, Switzerland) · 2023Article
- A Comparative Analysis of Chemical Constituents and Antioxidant Effects ofInternational journal of molecular sciences · 2023Article
- Effects of folic acid on oxidative damage of kidney in lead-exposed rats.Frontiers in nutrition · 2022Article
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Authors and funding
11 authors.
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Abstract
Background: Lead poisoning causes an oxidative stress response - a key "bridge" connecting various pathways - in the human body. Oxidative stress usually implies an imbalance between pro-oxidants and antioxidants. Moreover, Nrf2, Keap1, and TXNIP proteins play an essential role in oxidative stress. Some studies showed that pea peptides could alleviate the oxidative stress response. However, the effect and mechanism of pea peptide on oxidative stress response induced by lead in PC12 cells has not been reported. Aim: Investigating the effect and mechanism of pea peptides in alleviating oxidative damage in PC12 cells induced by lead. Methods: In this study, cell viability was measured by CCK8 (Cell Counting Kit-8). Superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), glutathione reductase (GR), glutathione peroxidase (GPx), reactive oxygen species (ROS), and lipid peroxidation (MDA) were measured using the corresponding Biochemical kits. The Keap1, Nrf2, and TXNIP protein expressions were tested using Western blot. Results: Pea peptides PP3, PP4, and PP6 could reverse the decrease of cell viability caused by lead exposure ( Conclusion: PP3, PP4, and PP6 can alleviate lead-induced oxidative stress damage in PC12 cells, and the Nrf2/Keap1/TXNIP signaling pathway may play an essential role in this process.
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