Evidence map›Paper›PMID 36034775›Full record

SynthesisFrontiers in pharmacology2022

N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review.

Anna Licata, Maria Giovanna Minissale, Simona Stankevičiūtė, Judith Sanabria-Cabrera, Maria Isabel Lucena, Raul J Andrade, Piero Luigi Almasio

Abstract readSystematic Review
In one paragraph

Synthesis in Frontiers in pharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Evaluating the Hepatoprotective Effect ofFood science & nutrition · 2026
    Article
  9. Drug Critical Limits for Urgent Physician Notification.Clinical pharmacology and therapeutics · 2026
    Article
  10. Article
  11. Article
  12. Redefining the role of the thiol-based agentRSC medicinal chemistry · 2026
    Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Anna LicataMedicina Interna ed Epatologia, Dipartimento di Promozione della Salute, Materno-infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro," PROMISE, Università degli Studi di Palermo, Palermo, Italy.
Maria Giovanna MinissaleMedicina Interna ed Epatologia, Dipartimento di Promozione della Salute, Materno-infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro," PROMISE, Università degli Studi di Palermo, Palermo, Italy.
Simona StankevičiūtėMedicina Interna ed Epatologia, Dipartimento di Promozione della Salute, Materno-infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro," PROMISE, Università degli Studi di Palermo, Palermo, Italy.
Judith Sanabria-CabreraUCICEC IBIMA, Plataforma SCReN (Spanish Clinical Research Network), Malaga, Spain.
Maria Isabel LucenaUCICEC IBIMA, Plataforma SCReN (Spanish Clinical Research Network), Malaga, Spain.
Raul J AndradeServicio de Aparato Digestivo, Instituto de Investigación Biomédica de Málaga-IBIMA, Hospital Universitario Virgen de la Victoria, Universidad de Málaga, Málaga, Spain.
Piero Luigi AlmasioMedicina Interna ed Epatologia, Dipartimento di Promozione della Salute, Materno-infantile, di Medicina Interna e Specialistica di Eccellenza "G. D'Alessandro," PROMISE, Università degli Studi di Palermo, Palermo, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

acetaminophendrug-induced liver injuryhepatotoxicityN-acetyl-cysteinesafety

Identifiers

PMID36034775
PMCPMC9399785

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.