ArticleNature cardiovascular research2022
Neutrophils incite and macrophages avert electrical storm after myocardial infarction.
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Article in Nature cardiovascular research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 2 of them syntheses that pooled it.
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77citing papers in PubMed, 2 pooled it
14.6field-weighted citation impact, top 1% of its field
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Who cites it
77 citing papers in PubMed, 2 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- Myocardial Immune Cells: The Basis of Cardiac Immunology.Journal of immunology (Baltimore, Md. : 1950) · 2023Pooled it
- Association between circulating leukocytes and arrhythmias: Mendelian randomization analysis in immuno-cardiac electrophysiology.Frontiers in immunology · 2023Pooled it
- Heart-specific T cell responses: from antigens to disease mechanisms.Nature reviews. Cardiology · 2026Review
- Myeloid Cell Expansion Propels Right Ventricular Dysfunction in HFpEF Through Sterile Inflammation.Circulation · 2026Article
- Enhanced myelopoiesis and myeloid TREM1 upregulation link obesity with adverse outcomes after myocardial infarction.Basic research in cardiology · 2026Article
- Tissue mitochondrial activity dictates the macrophage pool size.Science immunology · 2026Article
- Selective expansion of cardiac macrophage subtypes distinguishes their functional roles in disease and homeostasis.The Journal of clinical investigation · 2026Article
- The Immune System as a Proarrhythmic Mediator: A Novel Paradigm for the Development of New Antiarrhythmic Therapy.The Canadian journal of cardiology · 2026Review
- Emerging Roles for Metabolism in Myocardial Inflammation During Heart Failure.Immunological reviews · 2026Review
- Myocardial Immune Niches in Homeostasis and Inflammation.Immunological reviews · 2026Review
- Article
- Theoretical quantitative model and clinical outcome predictions of conductive cardiac patches for electrophysiological treatments.Nature biomedical engineering · 2026Article
- Rethinking Mitochondria: The Extracellular Dimension.Circulation research · 2026Review
- Interstitial cells and arrhythmia.American journal of physiology. Cell physiology · 2026Review
- Nervous Control of Myocardial Infarction Outcomes.JACC. Basic to translational science · 2026Article
- Models of cardiomyocyte-non-myocyte electrical interactions.The Journal of physiology · 2026Review
- Neutrophil Heterogeneity after Myocardial Infarction.Journal of innate immunity · 2026Review
- Cardiac resident macrophages: the emerging role in arrhythmogenesis.Frontiers in immunology · 2026Review
- Targeting efferocytosis for tissue regeneration: From microenvironment reprogramming to clinical translation.Theranostics · 2026Review
- Identification of a plasma proteomic signature associated with sudden cardiac death risk in the UK biobank.Frontiers in cardiovascular medicine · 2026Article
17 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 7 institutions in 3 countries.
Jana GruneCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Andrew J M LewisCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Masahiro YamazoeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Maarten HulsmansCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-1009-658X
David RohdeCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3785-9375
Ling XiaoCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5463-5576
Shuang ZhangCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Christiane OttDZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.ORCID 0000-0002-3199-0655
David M CalcagnoDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.ORCID 0000-0001-7022-9220
Yirong ZhouCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Kerstin TimmDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0001-9136-7518
Mayooran ShanmuganathanRadcliffe Department of Medicine, University of Oxford, Oxford, UK.ORCID 0000-0001-8036-6253
Fadi E PulousCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-0794-8078
Maximilian J SchlossCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Brody H FoyCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Diane CapenProgram in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Claudio VinegoniCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9818-3639
Gregory R WojtkiewiczCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-3148-8411
Yoshiko IwamotoCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Tilman GruneDZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, Germany.
Dennis BrownProgram in Membrane Biology, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
John HigginsCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-9182-0076
Vanessa M FerreiraRadcliffe Department of Medicine, University of Oxford, Oxford, UK.
Neil HerringNational Institute for Health (NIHR) Biomedical Research Centre, Oxford University Hospitals NHS Foundation Trust, John Radcliffe Hospital, Oxford, UK.ORCID 0000-0001-8453-6133
Keith M ChannonRadcliffe Department of Medicine, University of Oxford, Oxford, UK.
Stefan NeubauerRadcliffe Department of Medicine, University of Oxford, Oxford, UK.
Oxford Acute Myocardial Infarction (OxAMI) Study
David E SosnovikCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
David J MilanLeducq Foundation, Boston, MA, USA.
Filip K SwirskiCardiovascular Research Institute and Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3163-9152
Kevin R KingDepartment of Bioengineering, University of California, San Diego, La Jolla, CA, USA.
Aaron D AguirreCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-5509-1646
Patrick T EllinorCardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-2067-0533
Matthias NahrendorfCenter for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-4021-1887
Harvard University · USJohn Radcliffe Hospital · GBBroad Institute · USGerman Centre for Cardiovascular Research · DEUniversity of California San Diego · USUniversity of Oxford · GBBoston Foundation · US
Funding
Pilot & Feasibility ProgramP30DK043351 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI RAYMOND T CHUNG · 1991 to 2026
$35.3MTransgenic CoreP30DK057521 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI KAHN, BARBARA B. · 2000 to 2019
$31.4MIDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MPROJECT 4: Somatic evolution of the hematopoietic system in cardiovascular diseaseP01HL142494 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Benjamin Peter Kleinstiver · 2019 to 2026
$19.5MImaging organ system interfaces in ischemic heart diseaseR35HL139598 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI NAHRENDORF, MATTHIAS · 2018 to 2024
$6.9MMacrophages in homeostasis and cardiovascular diseaseR35HL135752 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI SWIRSKI, FILIP K · 2017 to 2023
$5.4MP&F programP30DK135043 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Aaron S Leong · 2023 to 2026
$5.4MCardiac resident macrophages in AV node conductionR01HL149647 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2022 to 2025
$2.9MMacrophage heterogeneity in atrial remodelingR01HL155097 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI HULSMANS, MAARTEN · 2021 to 2025
$2.9MElucidating Cell Communication Networks during Tissue Inflammation, Fibrosis, and RegenerationDP2AR075321 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI KING, KEVIN R · 2018 to 2018
$2.4MDynamic Single Cell Imaging of Coronary Microvascular Dysfunction in the Failing HeartR01HL144515 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AGUIRRE, AARON D · 2019 to 2023
$2.1MInterfering with the macrophage life cycle of atherosclerosisR01HL125428 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ANDERSON, DANIEL G, NAHRENDORF, MATTHIAS · 2017 to 2020
$1.9MBritish Heart Foundation CH/16/1/32013British Heart Foundation FS/16/7/31843British Heart Foundation FS/SCRF/20/32005British Heart Foundation FS/TF/20/33001British Heart Foundation PG/2019/34842NHLBI NIH HHS F32 HL158040NHLBI NIH HHS K24 HL105780NHLBI NIH HHS P01 HL142494NHLBI NIH HHS R00 HL129168NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL125428NHLBI NIH HHS R01 HL144515NHLBI NIH HHS R01 HL149647NHLBI NIH HHS R01 HL155097NHLBI NIH HHS R35 HL135752NHLBI NIH HHS R35 HL139598NIAMS NIH HHS DP2 AR075321NIBIB NIH HHS R21 EB026762NIDDK NIH HHS P30 DK043351NIDDK NIH HHS P30 DK057521NIDDK NIH HHS P30 DK135043
Abstract
Sudden cardiac death, arising from abnormal electrical conduction, occurs frequently in patients with coronary heart disease. Myocardial ischemia simultaneously induces arrhythmia and massive myocardial leukocyte changes. In this study, we optimized a mouse model in which hypokalemia combined with myocardial infarction triggered spontaneous ventricular tachycardia in ambulatory mice, and we showed that major leukocyte subsets have opposing effects on cardiac conduction. Neutrophils increased ventricular tachycardia via lipocalin-2 in mice, whereas neutrophilia associated with ventricular tachycardia in patients. In contrast, macrophages protected against arrhythmia. Depleting recruited macrophages in
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