Evidence map›Paper›PMID 36034696›Full record

ArticleFrontiers in cellular and infection microbiology2022

Differentiation of otitis media-causing bacteria and biofilms

Andrea K Locke, Farzana R Zaki, Sean T Fitzgerald, Kavya Sudhir, Guillermo L Monroy, Honggu Choi, Jungeun Won, Anita Mahadevan-Jansen, Stephen A Boppart

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Characterization of theInternational journal of molecular sciences · 2026
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  7. Assessment of photodynamic therapy efficacy againstJournal of biomedical optics · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Lactobacillus acidophilus VB1 co-aggregates and inhibits biofilm formation of chronic otitis media-associated pathogens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024
    Article
  12. Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024
    Review
  13. Article
  14. In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Observational
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Andrea K LockeVanderbilt Biophotonics Center, School of Engineering, Vanderbilt University, Nashville, TN, United States.
Farzana R ZakiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Sean T FitzgeraldVanderbilt Biophotonics Center, School of Engineering, Vanderbilt University, Nashville, TN, United States.
Kavya SudhirBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Guillermo L MonroyBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Honggu ChoiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Jungeun WonBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
Anita Mahadevan-JansenVanderbilt Biophotonics Center, School of Engineering, Vanderbilt University, Nashville, TN, United States.
Stephen A BoppartBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, United States.
University of Illinois Urbana-Champaign · USVanderbilt University · USIllinois College · US

Funding

Integration of Raman Spectroscopy and Optical Coherence Tomography (RS-OCT) for In-Vivo Identification of Bacterial Otitis MediaR01EB028615 · NIBIB · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A, MAHADEVAN-JANSEN, ANITA · 2019 to 2022
$2.5M
NIBIB NIH HHS R01 EB028615
6 · The paper itself

Abstract

In the management of otitis media (OM), identification of causative bacterial pathogens and knowledge of their biofilm formation can provide more targeted treatment approaches. Current clinical diagnostic methods rely on the visualization of the tympanic membrane and lack real-time assessment of the causative pathogen(s) and the nature of any biofilm that may reside behind the membrane and within the middle ear cavity. In recent years, optical coherence tomography (OCT) has been demonstrated as an improved

Indexed as

Otitis MediaSpectrum Analysis, RamanBacteriaBiofilmsHaemophilus influenzaeHumansTomography, Optical Coherencebacteriabacterial infectionbiofilmsbiophotonicsoptical coherence tomographyoptical spectroscopyotitis mediaRaman spectroscopy

Identifiers

PMID36034696
PMCPMC9400059
OpenAlexW4290988574

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.