Evidence map›Paper›PMID 36034515›Full record

ArticleJournal of clinical virology plus2022

Emergence and evolution of SARS-CoV-2 genetic variants during the Cuban epidemic.

María G Guzmán, Lissette Pérez, Yahisel Tejero, Dailyn Mederos, Mirtha E Aguado, Yanet Pintos, Odalys Valdes, Mayling Álvarez, Liena de Regla Ponce de León, Waldemar Baldoquín and 8 more

Abstract read
In one paragraph

Article in Journal of clinical virology plus, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

María G GuzmánDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Lissette PérezDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Yahisel TejeroDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Dailyn MederosDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Mirtha E AguadoCenter of Protein Studies, Faculty of Biology, University of Havana, Havana, Cuba.
Yanet PintosDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Odalys ValdesDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Mayling ÁlvarezDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Liena de Regla Ponce de LeónCenter of Protein Studies, Faculty of Biology, University of Havana, Havana, Cuba.
Waldemar BaldoquínDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Yenisleidys MartínezDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Claudia FigueredoDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Celine NaranjoDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Lirialys NuñesDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
Yanaris López AlmaguerDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.
José R de Armas FernándezMinistry of Public Health, Havana, Cuba.
José A Portal MirandaMinistry of Public Health, Havana, Cuba.
Vivian KouríDepartment of Virology, Pedro Kourí Tropical Medicine Institute, Havana, Cuba.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The SARS CoV-2 D614G variant circulated in Cuba in 2020. New viral variants were detected after the opening of the border in November 2020. We show the results of the genomic surveillance in Cuba from December 28, 2020, to September 28, 2021 and their relationship to the epidemiological situation in the country. A total of 1,406 nasopharyngeal exudates from COVID-19 patients were processed for RNA extraction and the 1836 bp fragment of the spike gene was amplified and sequenced. The mutations present were determined using the GISAID database. Prevalence ratios were estimated by fitting Poisson univariate and multivariate regression models to investigate associations between SARS-CoV-2 variant group (VOC, non-VOC) and disease outcome. Seventeen genetic variants were detected including VOC Alpha, Beta, Gamma and Delta, one variant of interest (VOI) (Lambda) and two previous VOI (A.2.5.1 and Zeta/P.2). Beta (34.77%), Delta (24.89%) and D614G (19%) variants were the most frequently detected. By June, Delta increased in frequency, displacing Beta. Disease severity increased significantly with age and VOC (PR =1.98, IC 95%: 1.33-3.05,

Indexed as

CubaSars cov-2SequencingS gene

Identifiers

PMID36034515
PMCPMC9394106

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.