ArticleFrontiers in molecular neuroscience2022
Alterations in local activity and functional connectivity in patients with postherpetic neuralgia after short-term spinal cord stimulation.
Article in Frontiers in molecular neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy and safety of short-term spinal cord stimulation and pulsed radiofrequency in the treatment of postherpetic neuralgia: a meta-analysis.Frontiers in neurology · 2025Pooled it
- Clinical practice guidelines for the management of refractory postherpetic neuralgia by the Korean Pain Society.The Korean journal of pain · 2026Review
- Impacts of Pain Characteristics on the Outcomes of Short-Term Spinal Cord Stimulation for the Treatment of Post-Herpetic Neuralgia: A Prospective Self-Controlled Study.Journal of pain research · 2026Article
- Structural and Functional Brain Alterations in Postherpetic Neuralgia: A Systematic Review and Voxel-Wise Coordinate-Based Meta-Analysis via the SDM-PSI Method.Journal of pain research · 2026Review
- Neural correlates of postoperative pain in patients with rotator cuff tear following arthroscopic surgery: a resting-state fMRI study.Scientific reports · 2025Article
- Abnormal Alterations of the White Matter Structural Network in Patients with Herpes Zoster and Postherpetic Neuralgia.Brain topography · 2025Article
- Resting-state brain functional connectivity in patients with chronic intractable pain who respond to spinal cord stimulation therapy.British journal of anaesthesia · 2025Article
- Central effects of short-term spinal cord stimulation in postherpetic neuralgia: a longitudinal fMRI and DTI study.Frontiers in neuroscience · 2025Article
- Mechanisms and clinical progress of spinal cord stimulation in refractory chronic pain: an overview.Frontiers in neurology · 2025Review
- Local Structural Indices Changes During Different Periods of Postherpetic Neuralgia: A Graphical Study in Structural Covariance Networks.Journal of pain research · 2025Article
- Amplitude of low-frequency fluctuations in classical trigeminal neuralgia patients with purely paroxysmal and concomitant continuous pain.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- A comprehensive review of the supraspinal mechanisms of spinal cord stimulation on chronic pain and cognition.Frontiers in pain research (Lausanne, Switzerland) · 2025Review
- Comparative efficacy of short-term spinal cord stimulation and pulsed radiofrequency in zoster-associated pain: a stratified database study.Frontiers in neurology · 2025Article
- Alterations in degree centrality and functional connectivity in tension-type headache: a resting-state fMRI study.Brain imaging and behavior · 2024Review
- Distinct Functional Connectivity Patterns for Intermittent Vs Constant Neuropathic Pain Phenotypes in Persistent Spinal Pain Syndrome Type 2 Patients.Journal of pain research · 2024Article
- Identification of Specific Abnormal Brain Functional Activity and Connectivity in Cancer Pain Patients: A Preliminary Resting-State fMRI Study.Journal of pain research · 2024Article
- Humoral Cytokine Levels in Patients with Herpes Zoster: A Meta-Analysis.Journal of pain research · 2024Review
- Abnormal Degree Centrality in Zoster-Associated Pain with or Without Psychiatric Comorbidities: A Resting-State Functional MRI Study.Journal of pain research · 2024Article
- Decreased Functional Connectivity of the Core Pain Matrix in Herpes Zoster and Postherpetic Neuralgia Patients.Brain sciences · 2023Article
- Alterations in regional homogeneity and multiple frequency amplitudes of low-frequency fluctuation in patients with new daily persistent headache: a resting-state functional magnetic resonance imaging study.The journal of headache and pain · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: The efficacy of short-term spinal cord stimulation (stSCS) as a treatment for neuropathic pain in patients with postherpetic neuralgia (PHN) has already been validated. However, the potential alterations in brain functionality that are induced by such treatment have yet to be completely elucidated. Methods: This study use resting-state functional magnetic resonance imaging (rs-fMRI) to detect the changes in regional homogeneity (ReHo) and degree centrality (DC) related to stimulator-induced pain relief in patients with PHN. A total of 10 patients with PHN underwent an MRI protocol at baseline and after stSCS. Alterations in ReHo and DC were then compared between baseline and after stSCS. We investigated the relationship between clinical parameters and functional changes in the brain. Results: Clinical parameters on pain, emotion, and sleep quality were correlated with ReHo and DC. ReHo and DC were significantly altered in the middle temporal gyrus, precuneus, superior frontal gyrus, supramarginal gyrus, inferior parietal lobule, rolandic operculum, middle occipital gyrus, superior parietal gyrus, and the precentral gyrus after stSCS. A significant correlation was detected between ReHo changes in the middle occipital gyrus, precuneus, inferior parietal gyrus, and changes in pain, emotion, and sleep quality. A significant negative correlation was detected between DC changes in the middle temporal gyrus, rolandic operculum, supramarginal gyrus, precuneus, inferior parietal gyrus, and changes in pain, emotion, and sleep quality. Conclusion: This study found that stSCS is able to induce ReHo and DC changes in patients with PHN, thus suggesting that stSCS can change brain function to alleviate pain, sleep, and emotional disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.