Evidence map›Paper›PMID 36034484›Full record

ArticleEnvironmental advances2022

The effect of residential proximity to brownfields, highways, and heavy traffic on serum metal levels in the Detroit Neighborhood Health Study.

Evans K Lodge, Nahnsan S Guseh, Chantel L Martin, Rebecca C Fry, Alexandra J White, Cavin K Ward-Caviness, Sandro Galea, Allison E Aiello

Abstract read
In one paragraph

Article in Environmental advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Arsenic, mercury, manganese, and lead exposure in Mexican adults aged 50 and older.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Evans K LodgeDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nahnsan S GusehCenter for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA.
Chantel L MartinDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Rebecca C FryDepartment of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Alexandra J WhiteEpidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.
Cavin K Ward-CavinessCenter for Public Health and Environmental Assessment, US Environmental Protection Agency, Chapel Hill, NC, USA.
Sandro GaleaSchool of Public Health, Boston University, Boston, MA, USA.
Allison E AielloDepartment of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

Funding

UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3M
Biostatstics for Research in Environmental HealthT32ES007018 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel, Rebecca Fry · 1985 to 2026
$31.3M
POPULATION STUDIEST32HD007168 · NICHD · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ELIZABETH A FRANKENBERG · 1985 to 2026
$13.8M
Environment and Cancer EpidemiologyZIAES103332 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI WHITE, ALEXANDRA · 2019 to 2025
$8.9M
Epigenomic Predictors of PTSD and Traumatic Stress in an African American CohortR01MD011728 · NIMHD · UNIVERSITY OF SOUTH FLORIDA · PI AIELLO, ALLISON E, UDDIN, MONICA · 2017 to 2025
$5.7M
Ecologic Stressors, PTSD, and Drug Use in DetroitR01DA022720 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI AIELLO, ALLISON E · 2007 to 2011
$4.7M
Socioenvironmental Causes of Elevated Toxic Metal Levels and Epigenetic AgingF30ES032302 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI LODGE, EVANS · 2021 to 2023
$124k
Intramural NIH HHS ZIA ES103332NICHD NIH HHS T32 HD007168NIDA NIH HHS R01 DA022720NIEHS NIH HHS F30 ES032302NIEHS NIH HHS P30 ES010126NIEHS NIH HHS T32 ES007018NIMHD NIH HHS R01 MD011728
6 · The paper itself

Abstract

Research in environmental sciences has demonstrated that land in close proximity to brownfields and heavily trafficked highways is contaminated with toxic metals. Despite this, little is known about the influence of brownfields and highways on metal levels in residents living nearby. We used data from 774 participants in the Detroit Neighborhood Health Study to estimate the effect of residential proximity to brownfields, highways, and present-day traffic on serum levels of lead, mercury, manganese, and copper using generalized estimating equations. We found that a 1 standard deviation increase in residential brownfield density within 200m was associated with increased serum lead levels (β: 0.04, 95% CI: -0.01, 0.09). The same modeled increase in a subset of historic industrial-use brownfields was associated with elevated serum mercury (β: 0.06, 95% CI: 0.03, 0.09). Increased highway and traffic density was positively associated with serum manganese (β: 0.02, 95% CI: 0.01, 0.04). Highway and traffic density was also positively associated with serum lead (β: 0.02, 95% CI: 0.01, 0.03) after restricting the analysis to participants who did not move during the study follow-up period. These findings draw attention to the importance of remediating polluted post-industrial sites in heavily populated areas, particularly as residents continue to move into densely populated cities around the globe.

Indexed as

brownfieldHghighwayMnPbtraffic

Identifiers

PMID36034484
PMCPMC9401556

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.