Evidence map›Paper›PMID 36034456›Full record

ArticleFrontiers in endocrinology2022

Case report: SARS-CoV-2 infection as a trigger for diabetic ketoacidosis and newly detected pancreatic autoantibodies.

Rahul Mishra, Ghada Elshimy, Lakshmi Kannan, Aasems Jacob, Rishi Raj

Open access · goldAbstract readCase Reports
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Rahul MishraDepartment of Hematology and Oncology, Cleveland Clinic Foundation, Cleveland, OH, United States.
Ghada ElshimyDepartment of Endocrinology, Diabetes, and Metabolism, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Lakshmi KannanDepartment of Nephrology, Pikeville Medical Center, Pikeville, KY, United States.
Aasems JacobDepartment of Hematology and Oncology, Pikeville Medical Center, Pikeville, KY, United States.
Rishi RajDepartment of Endocrinology, Diabetes, and Metabolism, Pikeville Medical Center, Pikeville, KY, United States.
Pikeville Medical Center · USAugusta University · USCleveland Clinic · USUniversity of Pikeville · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 39-year-old-woman with a past medical history of type 2 diabetes mellitus (T2DM) on oral hypoglycemic agents presented to the emergency room with nausea, vomiting, shortness of breath, and altered mental status. Seven days prior to presentation, she was diagnosed with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Laboratory workup on presentation confirmed the diagnosis of diabetic ketoacidosis (DKA) (blood glucose 523 mg/dl, beta-hydroxybutyrate 8.91 mmol/l, pH 6.9, bicarbonate 11 mEq/l, anion gap 25 mEq/l, and HbA1c 10.8%). She was managed for DKA with hydration and insulin drip and discharged home. However, to our surprise, at the 2-week follow-up visit, she was found to have positive antibodies for zinc transporter 8 (ZnT8) (samples were collected on day of presentation). The rest of her antibodies associated with T1DM were negative. She was therefore started on a basal-bolus regimen and managed as type 1 diabetes mellitus (T1DM). Our case illustrates that there is an increased risk of T1DM following infection with SARS-CoV-2.

Indexed as

COVID-19Diabetes Mellitus, Type 1Diabetes Mellitus, Type 2Diabetic KetoacidosisAdultAutoantibodiesFemaleHumansPancreatic HormonesSARS-CoV-2AutoantibodiesPancreatic HormonesautoantibodiesautoimminityCOVID – 19SARS – CoV – 2type 1 diabetes (T1D)

Identifiers

PMID36034456
PMCPMC9400714
OpenAlexW4292883117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.