Evidence map›Paper›PMID 36034417›Full record

ArticleFrontiers in endocrinology2022

Dexamethasone-associated metabolic effects in male mice are partially caused by depletion of endogenous corticosterone.

Lisa L Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sánchez-López, Jari F Scheerstra, Maaike C Voorhoeve, Ajith N Nadamuni Ramesh, Patrick C N Rensen, Martin Giera, Jan Kroon and 1 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Article
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  6. Modulatory role ofFrontiers in pharmacology · 2025
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  11. Supplementation with Vitamin DInternational journal of molecular sciences · 2023
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Lisa L KoorneefDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Merel van der MeulenDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Sander KooijmanDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Elena Sánchez-LópezCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Jari F ScheerstraDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Maaike C VoorhoeveDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Ajith N Nadamuni RameshDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Patrick C N RensenDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Martin GieraCenter for Proteomics and Metabolomics, Leiden University Medical Center, Leiden, Netherlands.
Jan KroonDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Onno C MeijerDepartment of Medicine, Division of Endocrinology, Leiden University Medical Center, Leiden, Netherlands.
Leiden University Medical Center · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic glucocorticoids are clinically used to treat auto-immune and inflammatory disease. Despite the high efficacy, glucocorticoid treatments causes side effects such as obesity and insulin resistance in many patients.

Indexed as

CorticosteroneGlucocorticoidsAnimalsDexamethasoneMaleMiceMice, Inbred C57BLReceptors, GlucocorticoidCorticosteroneDexamethasoneGlucocorticoidsReceptors, GlucocorticoidAldosteronecorticosteronedexamethasoneeplerenoneglucocorticoid receptorGR-MR crosstalkhypothalamus-pituitary-adrenal axismineralocorticoid receptor

Identifiers

PMID36034417
PMCPMC9399852
OpenAlexW4293677298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.