Epithelial arginase-1 is a key mediator of age-associated delayed healing in vaginal injury.

Holly N Wilkinson, Benjamin Reubinoff, David Shveiky, Matthew J Hardman, Ofra Ben Menachem-Zidon

Open access · goldAbstract read

In one paragraph

Article in Frontiers in endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 82% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Holly N WilkinsonCentre for Biomedicine, Hull York Medical School, University of Hull, Hull, United Kingdom.

Benjamin ReubinoffThe Hadassah Human Embryonic Stem Cell Research Center and the Goldyne Savad Institute of Gene Therapy, Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

David ShveikyDepartment of Obstetrics and Gynecology, Hadassah - Hebrew University Medical Center, Ein Kerem, Jerusalem, Israel.

Matthew J HardmanCentre for Biomedicine, Hull York Medical School, University of Hull, Hull, United Kingdom.

Ofra Ben Menachem-ZidonThe Hadassah Human Embryonic Stem Cell Research Center and the Goldyne Savad Institute of Gene Therapy, Medical Center and Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel.

Hebrew University of Jerusalem · ILHull York Medical School · GBHadassah Medical Center · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pelvic organ prolapse is a disorder that substantially affects the quality of life of millions of women worldwide. The greatest risk factors for prolapse are increased parity and older age, with the largest group requiring surgical intervention being post-menopausal women over 65. Due to ineffective healing in the elderly, prolapse recurrence rates following surgery remain high. Therefore, there is an urgent need to elucidate the cellular and molecular drivers of poor healing in pelvic floor dysfunction to allow effective management and even prevention. Recent studies have uncovered the importance of Arginase 1 for modulating effective healing in the skin. We thus employed novel

Indexed as

Pelvic Organ ProlapseSurgical MeshAgedAnimalsArginaseFemaleGynecologic Surgical ProceduresHumansQuality of LifeRatsARG1 protein, humanArginaseagingarginaseestrogenprolapse (POP)vaginal repairwound healing

Identifiers

PMID36034415

DOI10.3389/fendo.2022.927224

PMCPMC9410732

OpenAlexW4291017736

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.