ArticleFrontiers in neurology2022
The radiological and electrophysiological characteristics of Hirayama disease with proximal involvement: A retrospective study.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Hirayama Disease: Latest Insights into an Intriguing Disorder.Annals of Indian Academy of Neurology · 2026Article
- Hirayama and Granuloma-The Affinity Saga.Asian journal of neurosurgery · 2025Article
- In-Depth Understanding of Hirayama Disease: Dural Detachment Beyond Cervical Spine.Annals of Indian Academy of Neurology · 2025Article
- Radiological and Electrophysiological Correlates of Disease Progression in Patients with Hirayama Disease.Annals of Indian Academy of Neurology · 2025Article
- Characteristics of Hirayama Disease in Young South Korean Soldiers.Journal of clinical neurology (Seoul, Korea) · 2024Article
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12 authors.
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Abstract
Purpose: Hirayama disease (HD) has been largely believed to affect only distal muscles. However, the proximal upper extremities have been affected in some cases, which can be confused with motor neuron diseases. Methods: Baseline data, deep tendon reflex, Hoffmann sign, cervical curvature, sagittal Cobb angle, atrophied spinal cord, high signal intensity, loss of attachment, and affected muscles and segments on electromyography (EMG) were retrospectively obtained and compared between patients with HD with proximal involvement and patients with simple distal HD in one center from September 2007 to April 2022. Results: In this study, fifteen patients with proximal HD and 30 patients with simple distal HD were included. The proximal group had a larger proportion of patients with decreased biceps reflex, decreased triceps reflex, brisk or hyperactive knee reflex, positive Hoffmann sign, and cervical kyphosis. The curvatures of the upper part of the cervical spine (C2-4) were lost to a greater degree in the proximal group. More affected segments were observed on magnetic resonance imaging (MRI) and electromyography in the proximal group. Conclusion: The injured segments were longer and the upper curvature of the cervical spine was poorer in patients with HD with proximal involvement. These findings indicated that proximal involvement may indicate more serious HD.
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