ArticleFrontiers in neurology2022
Dynamic coupling between the central and autonomic cardiac nervous systems in patients with refractory epilepsy: A pilot study.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Heartbeat-Evoked Responses in M/EEG: A Systematic Review of Methods With Suggestions for Analysis and Reporting.Psychophysiology · 2026Pooled it
- Heartbeat-evoked potentials reveal interoceptive dysfunction in clinical disorders: Experimental frameworks and promising applications.Psychological medicine · 2026Review
- Autonomic and neural responses to varying transcutaneous cervical electrical stimulation parameters.Bioelectronic medicine · 2026Article
- Heart-Brain Temporal Coupling as a Candidate Biomarker of Self-Congruency.Biomedicines · 2026Article
- Human self and Neurosurgery: Advances and insights from Geneva.Brain & spine · 2025Review
- A narrative review of the mechanisms and consequences of intermittent hypoxia and the role of advanced analytic techniques in pediatric autonomic disorders.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
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Authors and funding
8 authors.
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Abstract
The heart and brain are reciprocally interconnected and engage in two-way communication for homeostatic regulation. Epilepsy is considered a network disease that also affects the autonomic nervous system (ANS). The neurovisceral integration model (NVM) proposes that cardiac vagal tone, indexed by heart rate variability (HRV), can indicate the functional integrity of cognitive neural networks. ANS activity and the pattern of oscillatory EEG activity covary during the transition of arousal states and associations between cortical and autonomic activity are reflected by HRV. Cognitive dysfunction is one of the common comorbidities that occur in epilepsy, including memory, attention, and processing difficulties. Recent studies have shown evidence for the active involvement of alpha activity in cognitive processes through its active role in the control of neural excitability in the cortex through top-down modulation of cortical networks. In the present pilot study, we evaluated the association between resting EEG oscillatory behavior and ANS function in patients with refractory epilepsy. Our results show: (1) In patients with refractory epilepsy, there is a strong positive correlation between HRV and the power of cortical oscillatory cortical activity in all studied EEG bands (delta, theta, alpha, and beta) in all regions of interest in both hemispheres, the opposite pattern found in controls which had low or negative correlation between these variables; (2) higher heartbeat evoked potential amplitudes in patients with refractory epilepsy than in controls. Taken together, these results point to a significant alteration in heart-brain interaction in patients with refractory epilepsy.
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