ArticleFrontiers in neurology2022
Association between thyroid function and disease severity in restless legs syndrome.
Article in Frontiers in neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Restless legs syndrome in pregnancy: Frequency, sleep quality, and questionnaire-defined risk of obstructive sleep apnea syndrome.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Restless legs syndrome and hashimoto's thyroiditis.Acta neurologica Belgica · 2026Article
- Energy Allocation Resilience and Endocrine Integration.International journal of molecular sciences · 2026Review
- Effects of Bariatric Surgery on Sleep Disorder Symptoms and Sleep Quality.Obesity surgery · 2025Article
- Neural Correlates of Restless Legs Syndrome (RLS) Based on Electroencephalogram (EEG)-A Mechanistic Review.International journal of molecular sciences · 2025Review
- Observational
- Analysis of thyroid function and related factors in narcolepsy patients.Scientific reports · 2023Article
- Emotional and behavioral features associated with subclinical hypothyroidism in children and adolescents with Down syndrome.Frontiers in psychology · 2023Article
- Circadian rhythm in restless legs syndrome.Frontiers in neurology · 2023Review
- Is Restless Legs Syndrome De Facto Thyroid Disease?Biomedicines · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Restless Legs Syndrome (RLS) is a common neurological disorder. Growing evidence shows that dopaminergic dysfunction and iron deficiency are associated with the pathogenesis of RLS. Additionally, the dopaminergic system is linked with the hypothalamic-pituitary-thyroid (HPT) axis. Thus, the current study aimed to compare thyroid function between RLS patients and healthy subjects and investigate the associations with clinical characteristics of RLS. Methods: Serum levels of thyroid hormones were investigated in 102 first-episode drug-naïve RLS patients and 80 matched healthy controls (HCs). Baseline data and clinical characteristics were performed by professional personnel. In addition, multivariate regression was used to analyze the relationship between thyroid function and RLS. Results: Compared with control group, RLS patients had significantly higher serum thyroid-stimulating hormone (TSH) levels ( Conclusion: Serum levels of TSH and the prevalence of subclinical hypothyroidism were higher in RLS patients, indicating the imbalance between thyroid hormones (TH) and the dopaminergic system may contribute to the development of primary RLS. Additionally, the TH axis may influence the quality of sleep in RLS patients.
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