ArticleiScience2022
A potent physiological method to magnify and sustain soleus oxidative metabolism improves glucose and lipid regulation.
Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute cognitive effects of interruptions to prolonged sitting with brief standing or physical activity breaks: a systematic review and three-level meta-analysis.The international journal of behavioral nutrition and physical activity · 2026Pooled it
- Effects of a low-load multi-component training program with blood flow restriction versus the same program without blood flow restriction on muscle thickness and functional outcomes in physically inactive young adults: randomized controlled trial.Frontiers in physiology · 2026Trial
- The metabolic effects of habitual leg shaking: A randomized crossover trial.Journal of diabetes · 2024Trial
- Immediate Circulating Cortisol Responses Differ Between Two Functionally Divergent Localized Resistance-Type Plantar Flexion and Elbow Flexions: An Exploratory Within-Participant Crossover Study.Life (Basel, Switzerland) · 2026Article
- Rectus femoris stiffness is associated with aerobic capacity in healthy young men: a comparative shear wave elastography study among lower-limb muscles.BMC musculoskeletal disorders · 2026Observational
- The skeletal muscle slow myosin heavy chain regulates mammalian metabolic homeostasis through the NRF2 pathway.Science advances · 2026Article
- Editorial: The distinct molecular and cardiometabolic characteristics of the soleus and slow oxidative muscle enhancing chronic disease prevention and healthy aging.Frontiers in endocrinology · 2026Article
- Morphological differences in myofibre size and shape: A comparative study of the soleus, gastrocnemius, triceps brachii and vastus lateralis in humans and mice.Journal of anatomy · 2026Article
- Silence of the Muscles: Wearable Electromyography, Sitting, and Type 2 Diabetes.Exercise and sport sciences reviews · 2025Review
- Effectiveness of a Participatory and Culturally Tailored Learning Program for Coronavirus Prevention in Muslim Older Adults With Hypertension and Diabetes: Quasi-Experimental Study.Asian/Pacific Island nursing journal · 2025Article
- Role of TRPV1Inflammopharmacology · 2025Article
- The Efficacy of Soleus Push-Up in Individuals with Prediabetes: A Pilot Study.Sports (Basel, Switzerland) · 2025Article
- Meeting report: the inaugural muscle biology and cachexia conference at the University of Houston, May 18-20, 2025, Houston, Texas, USA.Frontiers in physiology · 2025Article
- Physiological processes induced by different types of physical activity that either oppose or enhance postprandial glucose tolerance.Frontiers in endocrinology · 2025Review
- Quantification of nutrient fluxes during acute exercise in mice.Cell metabolism · 2024Article
- Review
- Exercise Prescription for Postprandial Glycemic Management.Nutrients · 2024Review
- Effect of Supplementation with Omega-3 Polyunsaturated Fatty Acids on Metabolic Modulators in Skeletal Muscle of Rats with an Obesogenic High-Fat Diet.Pharmaceuticals (Basel, Switzerland) · 2024Article
- Increased risk of type 2 diabetes after traumatic amputation: a nationwide retrospective cohort study.Frontiers in endocrinology · 2024Article
- Physiology of sedentary behavior.Physiological reviews · 2023Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Slow oxidative muscle, most notably the soleus, is inherently well equipped with the molecular machinery for regulating blood-borne substrates. However, the entire human musculature accounts for only ∼15% of the body's oxidative metabolism of glucose at the resting energy expenditure, despite being the body's largest lean tissue mass. We found the human soleus muscle could raise local oxidative metabolism to high levels for hours without fatigue, during a type of soleus-dominant activity while sitting, even in unfit volunteers. Muscle biopsies revealed there was minimal glycogen use. Magnifying the otherwise negligible local energy expenditure with isolated contractions improved systemic VLDL-triglyceride and glucose homeostasis by a large magnitude, e.g., 52% less postprandial glucose excursion (∼50 mg/dL less between ∼1 and 2 h) with 60% less hyperinsulinemia. Targeting a small oxidative muscle mass (∼1% body mass) with local contractile activity is a potent method for improving systemic metabolic regulation while prolonging the benefits of oxidative metabolism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.