Evidence map›Paper›PMID 36034219›Full record

ArticleiScience2022

Hypoxia-induced HMGB1 promotes glioma stem cells self-renewal and tumorigenicity via RAGE.

Cuifang Ye, Huan Li, Yachao Li, Yang Zhang, Guohao Liu, Hailong Mi, Honglian Li, Qungen Xiao, Li Niu, Xingjiang Yu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

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  20. Multiple functions of HMGB1 in cancer.Frontiers in oncology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Cuifang YeDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Huan LiDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Yachao LiDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Yang ZhangDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Guohao LiuDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Hailong MiDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Honglian LiDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Qungen XiaoDepartment of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.
Li NiuDepartment of Pathology, Zhongnan Hospital of Wuhan University, Wuhan 430071, P.R. China.
Xingjiang YuDepartment of Histology and Embryology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glioma stem cells (GSCs) in the hypoxic niches contribute to tumor initiation, progression, and recurrence in glioblastoma (GBM). Hypoxia induces release of high-mobility group box 1 (HMGB1) from tumor cells, promoting the development of tumor. Here, we report that HMGB1 is overexpressed in human GBM specimens. Hypoxia promotes the expression and secretion of HMGB1 in GSCs. Furthermore, silencing HMGB1 results in the loss of stem cell markers and a reduction in self-renewal ability of GSCs. Additionally, HMGB1 knockdown inhibits the activation of RAGE-dependent ERK1/2 signaling pathway and arrests the cell cycle in GSCs. Consistently, FPS-ZM1, an inhibitor of RAGE, downregulates HMGB1 expression and the phosphorylation of ERK1/2, leading to a reduction in the proliferation of GSCs. In xenograft mice of GBM, HMGB1 knockdown inhibits tumor growth and promotes mouse survival. Collectively, these findings uncover a vital function for HMGB1 in regulating GSC self-renewal potential and tumorigenicity.

Indexed as

Biological sciencesCancerCell biologyMicroenvironmentMolecular biology

Identifiers

PMID36034219
PMCPMC9399482

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.