Evidence map›Paper›PMID 36034141›Full record

ArticleFrontiers in aging neuroscience2022

Multimodal magnetic resonance imaging reveals distinct sensitivity of hippocampal subfields in asymptomatic stage of Alzheimer's disease.

Junjie Wu, Syed S Shahid, Qixiang Lin, Antoine Hone-Blanchet, Jeremy L Smith, Benjamin B Risk, Aditya S Bisht, David W Loring, Felicia C Goldstein, Allan I Levey and 2 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Junjie WuDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Syed S ShahidDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Qixiang LinDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Antoine Hone-BlanchetDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Jeremy L SmithDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Benjamin B RiskDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, GA, United States.
Aditya S BishtDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
David W LoringDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Felicia C GoldsteinDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Allan I LeveyDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
James J LahDepartment of Neurology, Emory University School of Medicine, Atlanta, GA, United States.
Deqiang QiuDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, United States.
Emory University · USIndiana University – Purdue University Indianapolis · USMassachusetts General Hospital · US

Funding

The Emory Healthy Brain Study: Discovering Predictive Biomarkers for Alzheimer's DiseaseR01AG070937 · NIA · EMORY UNIVERSITY · PI LAH, JAMES J · 2021 to 2025
$35.2M
The Goizueta Alzheimer's Disease Research CenterP30AG066511 · NIA · EMORY UNIVERSITY · PI Amy D Rodriguez · 2020 to 2026
$29.0M
Cerebral hemodynamic impairment in symptomatic and asymptomatic Alzheimer's DiseaseR01AG072603 · NIA · EMORY UNIVERSITY · PI Deqiang Qiu · 2022 to 2026
$3.8M
NIA NIH HHS P30 AG066511NIA NIH HHS R01 AG070937NIA NIH HHS R01 AG072603
6 · The paper itself

Abstract

While hippocampal atrophy and its regional susceptibility to Alzheimer's disease (AD) are well reported at late stages of AD, studies of the asymptomatic stage of AD are limited but could elucidate early stage pathophysiology as well as provide predictive biomarkers. In this study, we performed multi-modal magnetic resonance imaging (MRI) to estimate morphometry, functional connectivity, and tissue microstructure of hippocampal subfields in cognitively normal adults including those with asymptomatic AD. High-resolution resting-state functional, diffusion and structural MRI, cerebral spinal fluid (CSF), and neuropsychological evaluations were performed in healthy young adults (HY:

Indexed as

AD pathologyfunctional connectivityhippocampus subfieldsmorphometrynormal agingtissue microstructure

Identifiers

PMID36034141
PMCPMC9413400
OpenAlexW4293154072

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.