Evidence map›Paper›PMID 36034127›Full record

ArticleFrontiers in aging neuroscience2022

Effect of cognitive reserve on amnestic mild cognitive impairment due to Alzheimer's disease defined by fluorodeoxyglucose-positron emission tomography.

Takashi Kato, Yukiko Nishita, Rei Otsuka, Yoshitaka Inui, Akinori Nakamura, Yasuyuki Kimura, Kengo Ito, SEAD-J Study Group

Abstract read
In one paragraph

Article in Frontiers in aging neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [Research Progress in the Mechanisms of Acupuncture in Regulating DNA Methylation].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2025
    Review
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Takashi KatoDepartment of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Yukiko NishitaDepartment of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Rei OtsukaDepartment of Epidemiology of Aging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Yoshitaka InuiDepartment of Radiology, Fujita Health University School of Medicine, Aichi, Japan.
Akinori NakamuraDepartment of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Yasuyuki KimuraDepartment of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan.
Kengo ItoDepartment of Clinical and Experimental Neuroimaging, National Center for Geriatrics and Gerontology, Aichi, Japan.
SEAD-J Study Group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to investigate the effect of cognitive reserve (CR) on the rate of cognitive decline and cerebral glucose metabolism in amnestic mild cognitive impairment (MCI) using the Study on Diagnosis of Early Alzheimer's Disease-Japan (SEAD-J) dataset. The patients in SEAD-J underwent cognitive tests and fluorodeoxyglucose-positron emission tomography (FDG-PET). MCI to be studied was classified as amnestic MCI due to Alzheimer's disease (AD) with neurodegeneration. A total of 57 patients were visually interpreted as having an AD pattern (P1 pattern, Silverman's classification). The 57 individuals showing the P1 pattern were divided into a high-education group (years of school education ≥13,

Indexed as

Alzheimer’s disease (AD)cerebral glucose metabolismcognitive reserveeducationmild cognitive impairment

Identifiers

PMID36034127
PMCPMC9399434

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.