Evidence map›Paper›PMID 36034102›Full record

ReviewResearch (Washington, D.C.)2022

Bioimaging of Dissolvable Microneedle Arrays: Challenges and Opportunities.

Yanni Wang, Gehua Ma, Guangzhi Gao, Ji Tao, Wenzhao Cao, Haohao Sun, Fengsen Ma, Yilong Zhang, Yen Wei, Mei Tian

Abstract readReview
In one paragraph

Review in Research (Washington, D.C.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Pipeline of Devices and Aesthetics: What Is Left?The Journal of clinical and aesthetic dermatology · 2026
    Article
  3. Review
  4. Review
  5. [Rapamycin and HPPH Co-Loaded Nanodrug Delivered via Dissolvable Microneedles to Treat Port-Wine Stains].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yanni WangLaboratory of Biologics and Biomaterials, College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
Gehua MaCollege of Computer Science and Technology, Zhejiang University, Hangzhou 310027, China.
Guangzhi GaoLaboratory of Biologics and Biomaterials, College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.
Ji TaoHuman Phenome Institute, Fudan University, Shanghai 201203, China.
Wenzhao CaoHuman Phenome Institute, Fudan University, Shanghai 201203, China.
Haohao SunCollege of Information Engineering, Zhejiang University of Technology, Hangzhou 310023, China.
Fengsen MaLaboratory of Biologics and Biomaterials, College of Pharmacy, Zhejiang University of Technology, Hangzhou 310014, China.ORCID https://orcid.org/0000-0001-8389-0958
Yilong ZhangEngineering Research Center of Intelligent Sensing and System, Ministry of Education, Hangzhou 310023, China.ORCID https://orcid.org/0000-0002-1510-5097
Yen WeiDepartment of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing 100084, China.ORCID https://orcid.org/0000-0001-5950-0163
Mei TianHuman Phenome Institute, Fudan University, Shanghai 201203, China.ORCID https://orcid.org/0000-0002-1587-2114

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The emergence of microneedle arrays (MNAs) as a novel, simple, and minimally invasive administration approach largely addresses the challenges of traditional drug delivery. In particular, the dissolvable MNAs act as a promising, multifarious, and well-controlled platform for micro-nanotransport in medical research and cosmetic formulation applications. The effective delivery mostly depends on the behavior of the MNAs penetrated into the body, and accurate assessment is urgently needed. Advanced imaging technologies offer high sensitivity and resolution visualization of cross-scale, multidimensional, and multiparameter information, which can be used as an important aid for the evaluation and development of new MNAs. The combination of MNA technology and imaging can generate considerable new knowledge in a cost-effective manner with regards to the pharmacokinetics and bioavailability of active substances for the treatment of various diseases. In addition, noninvasive imaging techniques allow rapid, receptive assessment of transdermal penetration and drug deposition in various tissues, which could greatly facilitate the translation of experimental MNAs into clinical application. Relying on the recent promising development of bioimaging, this review is aimed at summarizing the current status, challenges, and future perspective on in vivo assessment of MNA drug delivery by various imaging technologies.

Identifiers

PMID36034102
PMCPMC9368514

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.