Evidence map›Paper›PMID 36033967›Full record

ArticleScandinavian journal of statistics, theory and applications2022

MULTIPLY ROBUST ESTIMATORS OF CAUSAL EFFECTS FOR SURVIVAL OUTCOMES.

Lan Wen, Miguel A Hernán, James M Robins

Abstract read
In one paragraph

Article in Scandinavian journal of statistics, theory and applications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Grace periods in comparative effectiveness studies of sustained treatments.Journal of the Royal Statistical Society. Series A, (Statistics in Society) · 2024
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lan WenDEPARTMENT OF EPIDEMIOLOGY, HARVARD T. H. CHAN SCHOOL OF PUBLIC HEALTH.
Miguel A HernánDEPARTMENT OF EPIDEMIOLOGY, HARVARD T. H. CHAN SCHOOL OF PUBLIC HEALTH.
James M RobinsDEPARTMENT OF EPIDEMIOLOGY, HARVARD T. H. CHAN SCHOOL OF PUBLIC HEALTH.

Funding

Alcohol Associated Outcomes Among HIV+/- Aging VeteransU10AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2006 to 2010
$12.7M
Alcohol Associated Outcomes Among HIV+/-Aging VeteransU01AA013566 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2002 to 2005
$10.1M
Alcohol and Multisubstance Use in the Veterans Aging Cohort StudyU01AA020790 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$7.7M
Sex Disparities in Overall Response to ART Among HIV Infected IndividualsU24AA020794 · NIAAA · YALE UNIVERSITY · PI JUSTICE, AMY CAROLINE · 2011 to 2020
$5.5M
Dynamic Strategies for the clinical management of HIV diseaseR37AI102634 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MIGUEL HERNAN · 2018 to 2026
$5.3M
Translational Research on Alcohol, Immunodeficiency, and Aging In COMpAAASU24AA022001 · NIAAA · YALE UNIVERSITY · PI BRANDT, CYNTHIA A. · 2012 to 2020
$3.2M
Alcohol Associated Outcomes Among HIV+/-Aging VeteransR01AA013566 · NIAAA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JUSTICE, AMY CAROLINE · 2001 to 2002
$1.6M
Training Program in Comparative Effectiveness Research for Suicide PreventionT32MH125815 · NIMH · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI MIGUEL HERNAN, MATTHEW K NOCK · 2022 to 2026
$1.2M
NIAAA NIH HHS R01 AA013566NIAAA NIH HHS U01 AA013566NIAAA NIH HHS U01 AA020790NIAAA NIH HHS U10 AA013566NIAAA NIH HHS U24 AA020794NIAAA NIH HHS U24 AA022001NIAID NIH HHS R37 AI102634NIMH NIH HHS T32 MH125815
6 · The paper itself

Abstract

Multiply robust estimators of the longitudinal g-formula have recently been proposed to protect against model misspecification better than the standard augmented inverse probability weighted estimator (Rotnitzky et al., 2017; Luedtke et al., 2018). These multiply robust estimators ensure consistency if one of the models for the treatment process or outcome process is correctly specified at each time point. We study the multiply robust estimators of Rotnitzky et al. (2017) in the context of a survival outcome. Specifically, we compare various estimators of the g-formula for survival outcomes in order to 1) understand how the estimators may be related to one another, 2) understand each estimator's robustness to model misspecification, and 3) construct estimators that can be more efficient than others in certain model misspecification scenarios. We propose a modification of the multiply robust estimators to gain efficiency under misspecification of the outcome model by using calibrated propensity scores over non-calibrated propensity scores at each time point. Theoretical results are confirmed via simulation studies, and a practical comparison of these estimators is conducted through an application to the US Veterans Aging Cohort Study.

Indexed as

augmented inverse probability weightingcausal inferenceestimating equationsiterative conditional expectationlocal efficiencymultiple robustness

Identifiers

PMID36033967
PMCPMC9401091

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.