ArticleFrontiers in microbiology2022
Deficiency of migration inhibitory factor influences the gut microbiota of C57BL/6 mice infected with
Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Microbe on the move:Journal of bacteriology · 2026Review
- Gut microbiota bidirectionally influences protection and severity in cerebral malaria in mice.Tropical medicine and health · 2026Article
- Comparative impacts of normobaric vs. hypobaric hypoxia on tissue integrity and gut microbiota in acute high-altitude murine models.Microbiology spectrum · 2026Article
- Multi-omics insights into the response of the gut microbiota and metabolites to albendazole deworming in captiveFrontiers in microbiology · 2025Article
- Review
- Mechanistic insights into the interaction between the host gut microbiome and malaria.PLoS pathogens · 2023Review
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Authors and funding
9 authors.
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Abstract
Cerebral malaria (CM), as one of the most common complications in severe malaria, has threatened millions of individuals' neurological health and even their lives. Macrophage migration inhibitory factor (MIF), a pleiotropic proinflammatory factor in humans, seems to be a risk factor for death in patients with CM, but its functional mechanism remains unclear. To verify whether affecting the intestinal microbes of the host was one of the mechanisms by which MIF regulates CM, C57BL/6 mice, including WT + PbA, MIF-KO + PbA and their uninfected controls, were sent for 16S rRNA-based sequencing targeting the V4 region of the intestinal microbiota through the Illumina MiSeq platform. The results showed that OTU clustering, alpha and beta diversity in the four groups involved had evident variation. The relative abundance at different taxonomic levels, especially the dominant intestinal flora, was obviously changed. The LEfSe analysis screened out several biomarkers, including significantly reduced
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