Evidence map›Paper›PMID 36033842›Full record

ArticleFrontiers in microbiology2022

Epidemiologic and clinical characteristics of human bocavirus infection in children hospitalized for acute respiratory tract infection in Qingdao, China.

Wenjing Wang, Renzheng Guan, Ziran Liu, Feng Zhang, Rui Sun, Sitong Liu, Xiaoyan Shi, Zhilei Su, Rongxiang Liang, Kangyu Hao and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wenjing WangDepartment of Epidemiology and Health Statistics, The College of Public Health of Qingdao University, Qingdao, China.
Renzheng GuanDepartment of Pediatrics, Affiliated Hospital of Qingdao University, Qingdao, China.
Ziran LiuQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Feng ZhangQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Rui SunQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Sitong LiuQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Xiaoyan ShiQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Zhilei SuQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Rongxiang LiangQingdao Municipal Center for Disease Control and Prevention, Qingdao, China.
Kangyu HaoDepartment of Epidemiology and Health Statistics, The College of Public Health of Qingdao University, Qingdao, China.
Zhaoguo WangDepartment of Epidemiology and Health Statistics, The College of Public Health of Qingdao University, Qingdao, China.
Xianming LiuDepartment of Neurosurgery, Qingdao Municipal Hospital, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent infection and prolonged shedding of human bocavirus 1 (HBoV1) in children have been reported, and the role of HBoV1 as a sole causative pathogen in acute respiratory infection (ARI) is yet to be established. While the reported prevalence of HBoV infection varies due to different detection methods and sampling criteria, determining the viral and bacterial etiology of HBoV infection using multiplex real-time PCR is yet to be reported. Herein, we aimed to further explore the pathogenicity of HBoV in patients with ARI by screening the viral and bacterial infections in children with ARI in Qingdao and comparing the epidemiological, clinical characteristics, and etiological results. Human bocavirus was identified in 28.1% of the samples, and further sequencing analysis of the detected HBoV confirmed 96.4% as HBoV1. The rate of HBoV as a single viral infection was 75%, and the rate of coinfection with bacteria was 66.1%, suggesting the need for continued monitoring of HBoV in children with ARIs. Clinical characterization suggested that HBoV infection may affect the function of organs, such as the liver, kidney, and heart, and the blood acid-base balance. Additionally, it is essential to promote awareness about the importance of disinfection and sterilization of the hospital environment and standardizing operations. The interactions between HBoV and other pathogens remain to be investigated in further detail in the future.

Indexed as

acute respiratory infectionsbacteriahuman bocavirusmultiplex real-time PCRStenotrophomonas maltophiliaviral infection

Identifiers

PMID36033842
PMCPMC9399728

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.