Evidence map›Paper›PMID 36033632›Full record

ArticleFrontiers in neuroscience2022

How brain-computer interface technology may improve the diagnosis of the disorders of consciousness: A comparative study.

Rossella Spataro, Yiyan Xu, Ren Xu, Giorgio Mandalà, Brendan Z Allison, Rupert Ortner, Alexander Heilinger, Vincenzo La Bella, Christoph Guger

Abstract read
In one paragraph

Article in Frontiers in neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. [Brain-computer interface technology and its applications for patients with disorders of consciousness].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Review
  7. [A portable steady-state visual evoked potential brain-computer interface system for smart healthcare].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2025
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Rossella SpataroIRCCS Centro Neurolesi Bonino Pulejo, Palermo, Italy.
Yiyan XuALS Clinical Research Center, University of Palermo, Palermo, Italy.
Ren Xug.tec Medical Engineering GmbH, Schiedlberg, Austria.
Giorgio MandalàRehabilitation Unit, Ospedale Buccheri La Ferla, Palermo, Italy.
Brendan Z AllisonCognitive Science Department, University of California, San Diego, San Diego, United States.
Rupert Ortnerg.tec Medical Engineering Spain S.L., Barcelona, Spain.
Alexander Heilingerg.tec Medical Engineering GmbH, Schiedlberg, Austria.
Vincenzo La BellaALS Clinical Research Center, University of Palermo, Palermo, Italy.
Christoph Gugerg.tec Medical Engineering GmbH, Schiedlberg, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Clinical assessment of consciousness relies on behavioural assessments, which have several limitations. Hence, disorder of consciousness (DOC) patients are often misdiagnosed. In this work, we aimed to compare the repetitive assessment of consciousness performed with a clinical behavioural and a Brain-Computer Interface (BCI) approach. Materials and methods: For 7 weeks, sixteen DOC patients participated in weekly evaluations using both the Coma Recovery Scale-Revised (CRS-R) and a vibrotactile P300 BCI paradigm. To use the BCI, patients had to perform an active mental task that required detecting specific stimuli while ignoring other stimuli. We analysed the reliability and the efficacy in the detection of command following resulting from the two methodologies. Results: Over repetitive administrations, the BCI paradigm detected command following before the CRS-R in seven patients. Four clinically unresponsive patients consistently showed command following during the BCI assessments. Conclusion: Brain-Computer Interface active paradigms might contribute to the evaluation of the level of consciousness, increasing the diagnostic precision of the clinical bedside approach. Significance: The integration of different diagnostic methods leads to a better knowledge and care for the DOC.

Indexed as

brain-computer interfaceComa Recovery Scale-Revisedcovert consciousnessminimally conscious stateunresponsive wakefulness syndromevegetative state

Identifiers

PMID36033632
PMCPMC9404379

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.