Evidence map›Paper›PMID 36033513›Full record

ArticleFrontiers in oncology2022

Osteoporosis, fracture and survival: Application of machine learning in breast cancer prediction models.

Lichen Ji, Wei Zhang, Xugang Zhong, Tingxiao Zhao, Xixi Sun, Senbo Zhu, Yu Tong, Junchao Luo, Youjia Xu, Di Yang and 3 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Lichen JiDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Wei ZhangDepartment of Orthopedics, Hangzhou Medical College People`s Hospital, Hangzhou, China.
Xugang ZhongDepartment of Orthopedics, Hangzhou Medical College People`s Hospital, Hangzhou, China.
Tingxiao ZhaoDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Xixi SunDepartment of Psychology and Behavioral Sciences, Zhejiang University, Hangzhou, China.
Senbo ZhuDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Yu TongDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Junchao LuoDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Youjia XuDepartment of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Di YangDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Yao KangDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.
Jin WangDepartment of Musculoskeletal Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China.
Qing BiDepartment of Orthopedics, Zhejiang Provincial People's Hospital, Hangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The risk of osteoporosis in breast cancer patients is higher than that in healthy populations. The fracture and death rates increase after patients are diagnosed with osteoporosis. We aimed to develop machine learning-based models to predict the risk of osteoporosis as well as the relative fracture occurrence and prognosis. We selected 749 breast cancer patients from two independent Chinese centers and applied six different methods of machine learning to develop osteoporosis, fracture and survival risk assessment models. The performance of the models was compared with that of current models, such as FRAX, OSTA and TNM, by applying ROC, DCA curve analysis, and the calculation of accuracy and sensitivity in both internal and independent external cohorts. Three models were developed. The XGB model demonstrated the best discriminatory performance among the models. Internal and external validation revealed that the AUCs of the osteoporosis model were 0.86 and 0.87, compared with the FRAX model (0.84 and 0.72)/OSTA model (0.77 and 0.66), respectively. The fracture model had high AUCs in the internal and external cohorts of 0.93 and 0.92, which were higher than those of the FRAX model (0.89 and 0.86). The survival model was also assessed and showed high reliability

Indexed as

breast cancerestrogenfracturemachine learningosteoporosisprognosis

Identifiers

PMID36033513
PMCPMC9417646

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.