ArticleMaterials today. Bio2022
Catechol-chitosan/polyacrylamide hydrogel wound dressing for regulating local inflammation.
Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Chronic Wound Healing: Research Advances from Pathological Mechanisms to Natural Herbal Active Ingredients and Material Delivery Systems.Molecules (Basel, Switzerland) · 2026Review
- Pro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication.Molecular biomedicine · 2026Review
- Antimicrobial Hydrogel for Diabetic Wound Treatment.International journal of nanomedicine · 2026Review
- Recent advances in polymer-based drug delivery systems for atopic dermatitis: enhancing therapeutic efficacy and outcomes.Materials today. Bio · 2025Review
- In Situ Formation of Silver Nanoparticles-Containing Gallic Acid-Conjugated Chitosan Hydrogels as Antimicrobial Tissue Adhesive Materials.Biomimetics (Basel, Switzerland) · 2025Article
- Immunomodulatory bioadhesive technologies.Biomaterials · 2025Review
- Article
- Accelerated dermal wound healing in diabetic mice by a HJournal of materials chemistry. B · 2025Article
- Synthesis, characterization, and application potential of chitosan/acrylamide composite hydrogels as skin expanders.Journal of materials science. Materials in medicine · 2024Article
- A bioenergetically-active ploy (glycerol sebacate)-based multiblock hydrogel improved diabetic wound healing through revitalizing mitochondrial metabolism.Cell proliferation · 2024Article
- Multi-functional composite dressings with sustained release of MSC-SLP and anti-adhesion property for accelerating wound healing.Materials today. Bio · 2024Article
- Recent Advances inGels (Basel, Switzerland) · 2023Review
- The Use of Specialized Pro-Resolving Mediators in Biomaterial-Based Immunomodulation.Journal of functional biomaterials · 2023Review
- Recent advances in responsive hydrogels for diabetic wound healing.Materials today. Bio · 2023Review
- Antimicrobial-Loaded Polyacrylamide Hydrogels Supported on Titanium as Reservoir for Local Drug Delivery.Pathogens (Basel, Switzerland) · 2023Article
- A biocompatible double-crosslinked gelatin/ sodium alginate/dopamine/quaterniazed chitosan hydrogel for wound dressings based on 3D bioprinting technology.International journal of bioprinting · 2023Article
- Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds and the accompanying inflammation are ongoing challenges in clinical treatment. They are usually accompanied by low pH and high oxidative stress environments, limiting cell growth and proliferation. Ordinary medical gauze has limited therapeutic effects on chronic wounds, and there is active research to develop new wound dressings. The chitosan hydrogel could be widely used in biomedical science with great biocompatibility, but the low mechanical properties limit its development. This work uses polyacrylamide to prepare double-network (DN) hydrogels based on bioadhesive catechol-chitosan hydrogels. Cystamine and N, N'-Bis(acryloyl)cystamine, which can be cross-linking agents with disulfide bonds to prepare redox-responsive DN hydrogels and pH-responsive nanoparticles (NPs) prepared by acetalized cyclodextrin (ACD) are used to intelligently release drugs against chronic inflammation microenvironments. The addition of catechol groups and ACD-NPs loaded with the Resolvin E1 (RvE1), promotes cell adhesion and regulates the inflammatory response at the wound site. The preparation of the DN hydrogel in this study can be used to treat and regulate the inflammatory microenvironment of chronic wounds accurately. It provides new ideas for using inflammation resolving factor loaded in DN hydrogel of good biocompatibility with enhanced mechanical properties to intelligent regulate the wound inflammation and promote the wound repaired.
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