Evidence map›Paper›PMID 36033105›Full record

ArticleBiological psychiatry global open science2021

Whole-Brain Resting-State Functional Connectivity Patterns Associated With Pediatric Anxiety and Involuntary Attention Capture.

Michael T Perino, Michael J Myers, Muriah D Wheelock, Qiongru Yu, Jennifer C Harper, Megan F Manhart, Evan M Gordon, Adam T Eggebrecht, Daniel S Pine, Deanna M Barch and 2 more

Abstract read
In one paragraph

Article in Biological psychiatry global open science, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Early-life neural correlates of behavioral inhibition and anxiety risk.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Neural Correlates of Novelty-Evoked Distress in 4-Month-Old Infants: A Synthetic Cohort Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024
    Article
  12. Review
  13. Article
  14. Novel mechanism-based treatments for pediatric anxiety and depressive disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Review
  15. Article
  16. Article
  17. From Connectivity to Clinical Translation: A Brain Network Model.Biological psychiatry global open science · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Michael T PerinoSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Michael J MyersSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Muriah D WheelockSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Qiongru YuDepartment of Psychology, San Diego State University, San Diego, California; Department of Psychiatry, University of California San Diego, San Diego, California.
Jennifer C HarperSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Megan F ManhartSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Evan M GordonSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Adam T EggebrechtSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Daniel S PineDevelopment & Emotion Branch, National Institute of Mental Health, Bethesda, Maryland.
Deanna M BarchSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Joan L LubySchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.
Chad M SylvesterSchool of Medicine, Washington University in St. Louis, St. Louis, Missouri.

Funding

Developmental Neuroscience and Child PsychopathologyT32MH100019 · NIMH · WASHINGTON UNIVERSITY · PI Deanna Barch, JOAN L. LUBY · 2013 to 2026
$4.8M
Neonatal Brain Activity and Risk for Anxiety Disorders in Early ChildhoodR01MH122389 · NIMH · WASHINGTON UNIVERSITY · PI Chad Michael Sylvester · 2020 to 2026
$3.9M
Illuminating development of infant and toddler brainfunction with DOTR01MH122751 · NIMH · WASHINGTON UNIVERSITY · PI EGGEBRECHT, ADAM THOMAS · 2020 to 2024
$2.7M
ATTENTION AND RELATED FUNCTIONAL BRAIN NETWORKS IN PEDIATRIC ANXIETY DISORDERSK23MH109983 · NIMH · WASHINGTON UNIVERSITY · PI SYLVESTER, CHAD MICHAEL · 2016 to 2020
$1.1M
Reward motivations associated with bullying trajectoriesR00HD105002 · NICHD · WASHINGTON UNIVERSITY · PI PERINO, MICHAEL T · 2023 to 2025
$732k
Network level analysis of progressive brain degeneration in autosomal dominant Alzheimer diseaseK99EB029343 · NIBIB · WASHINGTON UNIVERSITY · PI WHEELOCK, MURIAH D · 2020 to 2021
$484k
Reward motivations associated with bullying trajectoriesK99HD105002 · NICHD · WASHINGTON UNIVERSITY · PI PERINO, MICHAEL T · 2021 to 2022
$239k
NIBIB NIH HHS K99 EB029343NICHD NIH HHS K99 HD105002NICHD NIH HHS R00 HD105002NIMH NIH HHS K23 MH109983NIMH NIH HHS R01 MH122389NIMH NIH HHS R01 MH122751NIMH NIH HHS T32 MH100019
6 · The paper itself

Abstract

backgroundPediatric anxiety disorders are linked to dysfunction in multiple functional brain networks, as well as to alterations in the allocation of spatial attention. We used network-level analyses to characterize resting-state functional connectivity (rs-fc) alterations associated with 1) symptoms of anxiety and 2) alterations in stimulus-driven attention associated with pediatric anxiety disorders. We hypothesized that anxiety was related to altered connectivity of the frontoparietal, default mode, cingulo-opercular, and ventral attention networks and that anxiety-related connectivity alterations that include the ventral attention network would simultaneously be related to deviations in stimulus-driven attention.

methodsA sample of children (

resultsElevated clinician-rated anxiety was associated with altered connectivity within the cingulo-opercular network, as well as between the cingulo-opercular network and the ventral attention, default mode, and visual networks. Connectivity between the ventral attention and cingulo-opercular networks was associated with variation in both anxiety and stimulus-driven attention.

conclusionsPediatric anxiety is related to aberrant connectivity patterns among several networks, most of which include the cingulo-opercular network. These results help clarify the within- and between-network interactions associated with pediatric anxiety and its association with altered attention, suggesting that specific network connections could be targeted to improve specific altered processes associated with anxiety.

Identifiers

PMID36033105
PMCPMC9417088

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.