ArticleFrontiers in molecular biosciences2022
Pyroptosis in sepsis: Comprehensive analysis of research hotspots and core genes in 2022.
Article in Frontiers in molecular biosciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Immune molecular mechanisms of PANoptosis in sepsis-induced acute kidney injury.Inflammation and regeneration · 2026Review
- Peripheral immune phenotyping identifies an immunosuppressed sepsis endotype with potential relevance for immune stratification.Frontiers in immunology · 2026Article
- The role of ASIC2 in glioma progression: implications for prognosis and therapeutic targeting.PeerJ · 2026Article
- Sea dragon metabolome and lipidome unveil bioactive functional food candidates with sepsis therapeutic activities.NPJ science of food · 2025Article
- Review
- Exploration and verification of the therapeutic mechanism of shenfu injection in sepsis-induced myocardial injury.PloS one · 2025Article
- Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers.Cancers · 2024Article
- Immunoadjuvant therapy in the regulation of cell death in sepsis: recent advances and future directions.Frontiers in immunology · 2024Review
- Grape Seed Proanthocyanidin Ameliorates LPS-induced Acute Lung Injury By Modulating M2a Macrophage Polarization Via the TREM2/PI3K/Akt Pathway.Inflammation · 2023Article
- Predicting the prognosis in patients with sepsis by a pyroptosis-related gene signature.Frontiers in immunology · 2022Article
- Stachydrine Alleviates Sepsis-Induced Cardiomyopathy by Inhibiting Ferroptosis via Regulating SIRT1/GPX4 Pathway.Dose-response : a publication of International Hormesis SocietyArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sepsis, a life-threatening disease caused by dysregulated host response to infection, is a major public health problem with a high mortality and morbidity rate. Pyroptosis is a new type of programmed cell death discovered in recent years, which has been proved to play an important role in sepsis. Nevertheless, there is no comprehensive report, which can help researchers get a quick overview and find research hotspots. Thus, we aimed to identify the study status and knowledge structures of pyroptosis in sepsis and summarize the key mechanism of pyroptosis in sepsis. The data were retrieved and downloaded from the WOS database. Software such as VOSviewer was used to analyze these publications. Key genes were picked out by using (https://www.genecards.org) and (http://www.bioinformatics.com). Then, Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were used to performed these key genes. From 2011 to 2021, a total of 299 papers met the search criteria, and the global interest in pyroptosis in sepsis measured by the value of (RRI) has started to increase since 2016. China ranked first in the number of publications, followed by the USA. The journal
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