ArticleBiomedical optics express2022
Label free optical transmission tomography for biosystems: intracellular structures and dynamics.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Metabolic imaging ofBiomedical optics express · 2026Article
- Back-illumination interference tomography for imaging weak scattering in thick tissues.Optica · 2025Article
- Transmission interference microscopy of anterior human eye.Nature communications · 2025Article
- Label-Free Optical Transmission Tomography for Direct Mycological Examination and Monitoring of Intracellular Dynamics.Journal of fungi (Basel, Switzerland) · 2024Article
- Probing chromatin condensation dynamics in live cells using interferometric scattering correlation spectroscopy.Communications biology · 2024Article
- Optical tomography in a single camera frame using fringe-encoded deep-learning full-field OCT.Biomedical optics express · 2024Article
- Comparative analysis of full-field OCT and optical transmission tomography.Biomedical optics express · 2023Article
- Interface self-referenced dynamic full-field optical coherence tomography.Biomedical optics express · 2023Article
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Authors and funding
5 authors.
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Abstract
There is an increasing need for label free methods that could reveal intracellular structures and dynamics. In this context, we develop a new optical tomography method working in transmission - full-field optical transmission tomography (FF-OTT). The method can measure the forward scattering signals and reveals the time-dependent metabolic signals in living cells. FF-OTT is a common path interferometer taking advantage of the Gouy phase shift - a π phase shift that the light wave experiences around the focus. By modulating the position of the focus one can alter the phase of the scattered light. Demodulation of images with different phases rejects the background and enhances the light from the depth-of-field, thus producing an optical section. We test FF-OTT by imaging single-cell diatoms and ex vivo biological samples. In fresh samples, we show that the intracellular motions create visible intensity fluctuations in FF-OTT so that the method is able to reveal a metabolic dynamic contrast. FF-OTT was found to be an efficient label free technique that can be readily implemented thanks to a robust common-path speckle-free interferometer design using an incoherent light source.
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Registered trials
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