ArticleBiomedical optics express2022
Local axis orientation mapped by polarization sensitive optical coherence tomography provides a unique contrast to identify caries lesions in enamel.
Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Photonic Methods for the Assessment of Lesion Activity.Diagnostics (Basel, Switzerland) · 2026Review
- High-speed, wide-field, fiber-based PS-OCT system with real-time surface Stokes feedback for circular input polarization.Biomedical optics express · 2026Article
- Collagen microarchitecture from polarized light imaging: a biomechanics perspective.Journal of biomedical optics · 2026Review
- Three-dimensional fiber orientation mapping of ex vivo human brain at micrometer resolution.Npj imaging · 2025Article
- Adaptive contour-tracking to aid wide-field swept-source optical coherence tomography imaging of large objects with uneven surface topology.Biomedical optics express · 2024Article
- Visualization enhancement by PCA-based image fusion for skin burns assessment in polarization-sensitive OCT.Biomedical optics express · 2024Article
- High-speed, long-range and wide-field OCT for in vivo 3D imaging of the oral cavity achieved by a 600 kHz swept source laser.Biomedical optics express · 2024Article
- Visualization of carious lesions with polarized and depolarized light microscopy.Biomedical optics express · 2024Article
- Digital calibration method to enable depth-resolved all-fiber polarization sensitive optical coherence tomography with an arbitrary input polarization state.Biomedical optics express · 2024Article
- Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review.Dentistry journal · 2023Review
- Integrating a pressure sensor with an OCT handheld probe to facilitate imaging of microvascular information in skin tissue beds.Biomedical optics express · 2022Article
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Authors and funding
7 authors.
Funding
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Abstract
Due to rod-like hydroxyapatite crystal organizations, dental enamel is optically anisotropic, i.e., birefringent. Healthy enamel is known to be intrinsically negatively birefringent. However, when demineralization of enamel occurs, a considerable number of inter-crystallite spaces would be created between the crystallites in the enamel, which could lead to a sign reversion in birefringence of the enamel structure. We propose that this sign reversion can be leveraged in polarization sensitive OCT (PSOCT) imaging to differentiate early caries lesions from healthy enamel. In this study using PSOCT, we first confirm that the change in birefringence sign (negative to positive) can lead to a 90-degree alteration in the local axis orientation because of the switch between the fast and slow optic axes. We then demonstrate, for the first time, that the local axis orientation can be utilized to map and visualize the WSLs from the healthy enamel with a unique contrast. Moreover, the sharp alteration in local axis orientation gives a clear boundary between the WSLs and the healthy enamel, providing an opportunity to automatically segment the three-dimensional WSLs from the healthy enamel, enabling the characterization of their size and depth information in an intuitive way, which may aid clinical decision making and treatment planning.
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