Evidence map›Paper›PMID 36032565›Full record

ArticleBiomedical optics express2022

Direct characterization of tissue dynamics with laser speckle contrast imaging.

Shuqi Zheng, Jerome Mertz

Abstract read
In one paragraph

Article in Biomedical optics express, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Shuqi ZhengDepartment of Electrical and Computer Engineering, Boston University, 8 St. Mary's St. Boston MA 02215, USA.ORCID https://orcid.org/0000-0003-3309-1909
Jerome MertzDepartment of Biomedical Engineering, Boston University, 44 Cummington Mall, Boston MA 02215, USA.ORCID https://orcid.org/0000-0002-6343-9155

Funding

Fast, large-scale neuronal imaging with multi-z confocal microscopyR01EB029171 · NIBIB · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI MERTZ, JEROME · 2020 to 2023
$1.8M
NIBIB NIH HHS R01 EB029171
6 · The paper itself

Abstract

Laser speckle contrast imaging (LSCI) has gained broad appeal as a technique to monitor tissue dynamics (broadly defined to include blood flow dynamics), in part because of its remarkable simplicity. When laser light is backscattered from a tissue, it produces speckle patterns that vary in time. A measure of the speckle field decorrelation time provides information about the tissue dynamics. In conventional LSCI, this measure requires numerical fitting to a specific theoretical model for the field decorrelation. However, this model may not be known a priori, or it may vary over the image field of view. We describe a method to reconstruct the speckle field decorrelation time that is completely model free, provided that the measured speckle dynamics are ergodic. We also extend our approach to allow for the possibility of non-ergodic measurements caused by the presence of a background static speckle field. In both ergodic and non-ergodic cases, our approach accurately retrieves the correlation time without any recourse to numerical fitting and is largely independent of camera exposure time. We apply our method to tissue phantom and

Identifiers

PMID36032565
PMCPMC9408238

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.