Evidence map›Paper›PMID 36032523›Full record

ArticleJACS Au2022

New Benchmark in DNA-Based Asymmetric Catalysis: Prevalence of Modified DNA/RNA Hybrid Systems.

Nicolas Duchemin, Sidonie Aubert, João V de Souza, Lucas Bethge, Stefan Vonhoff, Agnieszka K Bronowska, Michael Smietana, Stellios Arseniyadis

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in JACS Au, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolas DucheminQueen Mary University of London, Department of Chemistry, Mile End Road, London E1 4NS, United Kingdom.
Sidonie AubertQueen Mary University of London, Department of Chemistry, Mile End Road, London E1 4NS, United Kingdom.
João V de SouzaChemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle NE1 7RU, United Kingdom.
Lucas BethgeNOXXON Pharma AG, Max-Dohrn-Strasse 8-10, Berlin 10589, Germany.
Stefan VonhoffNOXXON Pharma AG, Max-Dohrn-Strasse 8-10, Berlin 10589, Germany.
Agnieszka K BronowskaChemistry-School of Natural and Environmental Sciences, Newcastle University, Newcastle NE1 7RU, United Kingdom.
Michael SmietanaInstitut des Biomolécules Max Mousseron, Université de Montpellier, CNRS, ENSCM, 1919 Route de Mende, Montpellier 34095, France.ORCID https://orcid.org/0000-0001-8132-7221
Stellios ArseniyadisQueen Mary University of London, Department of Chemistry, Mile End Road, London E1 4NS, United Kingdom.ORCID https://orcid.org/0000-0001-6831-2631

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

By harnessing the chirality of the DNA double helix, chemists have been able to obtain new, reliable, selective, and environmentally friendly biohybrid catalytic systems with tailor-made functions. Nonetheless, despite all the advances made throughout the years in the field of DNA-based asymmetric catalysis, many challenges still remain to be faced, in particular when it comes to designing a "universal" catalyst with broad reactivity and unprecedented selectivity. Rational design and rounds of selection have allowed us to approach this goal. We report here the development of a DNA/RNA hybrid catalytic system featuring a covalently attached bipyridine ligand, which exhibits unmatched levels of selectivity throughout the current DNA toolbox and opens new avenues in asymmetric catalysis.

Identifiers

PMID36032523
PMCPMC9400053

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.