Evidence map›Paper›PMID 36032288›Full record

ArticleFrontiers in veterinary science2022

Clinical evaluation of toll-like receptor-5 agonist for radiation-induced oral mucositis in beagle dogs.

Jaeeun Ko, Jaehwan Kim, Yang-Kyu Choi, Sang-Soep Nahm, Jayon Kim, Sun-Min Seo, Jin-Seok Seo, Woojong Lee, Weon Kuu Chung, Kidong Eom

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in veterinary science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Radiomitigators: Breakthroughs in Post-Radiation Recovery.Antioxidants (Basel, Switzerland) · 2026
    Review
  2. Unraveling the complexity of radiotherapy- and chemotherapy-induced oral mucositis: insights into pathogenesis and intervention strategies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Review
  3. The Role of the Innate Immune Response in Oral Mucositis Pathogenesis.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jaeeun KoDepartment of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Jaehwan KimDepartment of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Yang-Kyu ChoiDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Sang-Soep NahmDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Jayon KimDepartment of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Sun-Min SeoDepartment of Laboratory Animal Medicine, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Jin-Seok SeoDepartment of Anatomy, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.
Woojong LeeConnext Co. Ltd., Daegu, South Korea.
Weon Kuu ChungDepartment of Radiation Oncology, Kyung Hee University Hospital at Gangdong, Seoul, South Korea.
Kidong EomDepartment of Veterinary Medical Imaging, College of Veterinary Medicine, Konkuk University, Seoul, South Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed to evaluate the clinical safety and validate the radiomitigative effect of KMRC011, against radiation-induced oral mucositis in beagle dogs. Clinical safety was evaluated by assessing tolerability, complete blood tests, and plasma biochemistry after drug administration. The radiomitigative effect of KMRC011 was evaluated macropathologically and histopathologically after inducing oral mucositis iatrogenically using 20 Gy irradiation. The plasma concentration of interleukin-6 was measured

Indexed as

dogflagellinradiation countermeasureradiotherapytoll-like receptor-5

Identifiers

PMID36032288
PMCPMC9412099

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.