ArticleFrontiers in psychiatry2022
Peripheral inflammation levels associated with degree of advanced brain aging in schizophrenia.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- The effect of dual inflammation on the acute phase clinical outcomes of schizophrenia patients with comorbid COVID-19.Brain, behavior, & immunity - health · 2025Article
- Article
- Limited evidence of association between dysregulated immune marker levels and telomere length in severe mental disorders.Acta neuropsychiatrica · 2025Article
- Lithium, Inflammation and Neuroinflammation with Emphasis on Bipolar Disorder-A Narrative Review.International journal of molecular sciences · 2024Review
- Elucidating Multimodal Imaging Patterns in Accelerated Brain Aging: Heterogeneity through a Discriminant Analysis Approach Using the UK Biobank Dataset.Bioengineering (Basel, Switzerland) · 2024Article
- Microglia-neuron interactions in schizophrenia.Frontiers in cellular neuroscience · 2024Review
- Review of Major Social Determinants of Health in Schizophrenia-Spectrum Psychotic Disorders: III. Biology.Schizophrenia bulletin · 2023Article
- Investigating brain aging trajectory deviations in different brain regions of individuals with schizophrenia using multimodal magnetic resonance imaging and brain-age prediction: a multicenter study.Translational psychiatry · 2023Article
- Predicting aging trajectories of decline in brain volume, cortical thickness and fractional anisotropy in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain structural abnormalities have been demonstrated in schizophrenia (SZ); these resemble those seen in typical aging, but are seen at younger ages. Furthermore, SZ is associated with accelerated global brain aging, as measured by brain structure-based brain predicted age difference (Brain-PAD). High heterogeneity exists in the degree of brain abnormalities in SZ, and individual differences may be related to levels of peripheral inflammation and may relate to cognitive deficits and negative symptoms. The goal of our study was to investigate the relationship between brain aging, peripheral inflammation, and symptoms of SZ. We hypothesized older brain-PAD in SZ vs. healthy comparison (HC) participants, as well as positive relationships of brain-PAD with peripheral inflammation markers and symptoms in SZ. We analyzed data from two cross-sectional studies in SZ (
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