Evidence map›Paper›PMID 36032226›Full record

ArticleFrontiers in psychiatry2022

Recurrent suicide attempts affect normalization of HPA axis dysregulation after recovery from major depression.

Johannes M Hennings, Marcus Ising, Manfred Uhr, Florian Holsboer, Susanne Lucae

Abstract read
In one paragraph

Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. The HPA Axis as Target for Depression.Current neuropharmacology · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Johannes M HenningsTranslational Department, Max Planck Institute of Psychiatry, Munich, Germany.
Marcus IsingTranslational Department, Max Planck Institute of Psychiatry, Munich, Germany.
Manfred UhrTranslational Department, Max Planck Institute of Psychiatry, Munich, Germany.
Florian HolsboerTranslational Department, Max Planck Institute of Psychiatry, Munich, Germany.
Susanne LucaeTranslational Department, Max Planck Institute of Psychiatry, Munich, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

More than 700,000 people worldwide die by suicide every year, and the number of suicide attempts is estimated as 20 times higher, most of them being associated with psychiatric disorders, especially major depression. Knowledge about effective methods for preventing suicide attempts in individuals at high risk for suicide is still scarce. Dysregulation of the neuroendocrine stress response system,

Indexed as

depressionDEX/CRH (dexamethasone/corticotropin releasing hormone) testHPAsuicidalitysuicide attempt

Identifiers

PMID36032226
PMCPMC9412752

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.