ArticleFrontiers in psychiatry2022
An exploratory study of pro-inflammatory cytokines in individuals with alcohol use disorder: MCP-1 and IL-8 associated with alcohol consumption, sleep quality, anxiety, depression, and liver biomarkers.
Article in Frontiers in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Noninvasive Vagus Nerve Stimulation Reduces Withdrawal-Related Affective Distress and Improves Functional Outcomes in Alcohol Use Disorder: A Feasibility and Acceptability Pilot Study.Neuromodulation : journal of the International Neuromodulation Society · 2025Trial
- Longitudinal changes in sleep quality in male patients with alcohol dependence receiving far-infrared ray therapy: associations with alterations in circulating pro-inflammatory cytokines.BMC psychiatry · 2025Trial
- Towards Mechanism-Informed Treatments for Mental Health.Journal of neurochemistry · 2026Review
- From alpha diversity to zeitgebers: Functional implications and potential mechanisms linking the gut microbiome to sleep and circadian disruption (Part II).Neuroscience and biobehavioral reviews · 2026Review
- Cytokine Networks in Alcohol Use Disorder: A Narrative Review Highlighting Research Gaps and Future Priorities.Medical sciences (Basel, Switzerland) · 2026Review
- Sleep disturbance is associated with greater subjective and neural negative emotionality in people with alcohol use disorder.Drug and alcohol dependence · 2026Article
- The effect of neuroimmune signalling on drug addiction.Frontiers in pharmacology · 2026Review
- Sleep alterations in substance use disorders: a systematic review and meta-analysis.EClinicalMedicine · 2026Article
- Relationship between microplastics in stool, diet, and inflammatory markers in healthy Japanese individuals.Environmental health and preventive medicine · 2026Article
- Anxiety is associated with systemic pro-inflammatory profile and plasma lipid changes in Mexican young adults.Frontiers in cellular neuroscience · 2026Article
- Mindfulness-based intervention for patients with generalized anxiety disorder: a randomized controlled trial.Frontiers in psychiatry · 2026Article
- Associations of serum TNF-α, IL-8, and IL-18 levels with the clinical symptoms in acute schizophrenia: a cross-sectional study.BMC psychiatry · 2025Article
- Targeting IL-6 as a novel therapeutic approach for alcohol abstinence - related mechanical allodynia.Neuropharmacology · 2025Article
- Alcohol alters blood-testis barrier function in an in vitro model.F&S science · 2025Article
- Anxiety and depression status in geriatric patients undergoing total hip arthroplasty: Correlation with postoperative pain and risk factors.World journal of psychiatry · 2025Article
- Identification of Interleukin-1β in Whole Blood as a Candidate Biomarker for Alcohol Use Disorder Risk Based on AUDIT Scores.Addiction biology · 2025Article
- An exploratory study of cytokine and inflammatory profiles between young adult low-risk and at-risk drinkers.Alcohol (Fayetteville, N.Y.) · 2025Article
- Neuroimmune regulation of the prefrontal cortex tetrapartite synapse.Neuropharmacology · 2025Review
- Multiplex Immunoassay for Biomarker Profiling of Whole Blood Cell Lysates and Supernatants and Pathogen Response in Neat Whole Blood Cultures.Methods and protocols · 2025Article
- Alterations in fecal microbiota composition and cytokine expression profiles in adolescents with depression: a case-control study.Scientific reports · 2025Article
Corrections and comments
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Authors and funding
10 authors.
Funding
Abstract
Background: High levels of sleep disturbances reported among individuals with alcohol use disorder (AUD) can stimulate inflammatory gene expression, and in turn, may alter pro-inflammatory cytokines levels. We aimed to investigate associations between pro-inflammatory cytokine markers with subjective measures of sleep quality, psychological variables and alcohol consumption among individuals with AUD. Methods: This exploratory study is comprised of individuals with AUD ( Results: The AUD group was significantly older, with poorer sleep quality, higher anxiety/depression scores, and higher average drinks per day as compared to controls. Within the AUD group, IL-8 and MCP-1 had positive significant correlations with sleep, anxiety, depression and drinking variables. Specifically, higher levels of MCP-1 were associated with poorer sleep ( Conclusion: This exploratory analysis revealed associations with cytokines MCP-1 and IL-8 and drinking consumption, sleep quality, and anxiety and depression in the AUD group. Furthermore, inflammatory and liver markers were highly correlated with certain pro-inflammatory cytokines in the AUD group suggesting a possible relationship between chronic alcohol use and inflammation. These associations may contribute to prolonged inflammatory responses and potentially higher risk of co-morbid chronic diseases.
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