Evidence map›Paper›PMID 36032216›Full record

ArticleResearch and practice in thrombosis and haemostasis2022

Hormonal therapies and venous thrombosis: Considerations for prevention and management.

Corinne LaVasseur, Suvi Neukam, Thomas Kartika, Bethany Samuelson Bannow, Joseph Shatzel, Thomas G DeLoughery

Open access · goldAbstract read
In one paragraph

Article in Research and practice in thrombosis and haemostasis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
15.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

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  10. SheVari4Food & nutrition research · 2026
    Article
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  12. Residual disease volume and prognosis in endometrioid precancer after progestin therapy.Virchows Archiv : an international journal of pathology · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Corinne LaVasseurDepartment of Medicine Oregon Health and Sciences University Portland Oregon USA.
Suvi NeukamDepartment of Medicine Oregon Health and Sciences University Portland Oregon USA.
Thomas KartikaDivision of Hematology-Oncology Oregon Health and Sciences University Portland Oregon USA.ORCID https://orcid.org/0000-0003-3926-7127
Bethany Samuelson BannowDepartment of Medicine Oregon Health and Sciences University Portland Oregon USA.ORCID https://orcid.org/0000-0002-9981-8990
Joseph ShatzelDepartment of Medicine Oregon Health and Sciences University Portland Oregon USA.
Thomas G DeLougheryDepartment of Medicine Oregon Health and Sciences University Portland Oregon USA.ORCID https://orcid.org/0000-0002-5790-4700
Oregon Health & Science University · US

Funding

Evaluating the Safety and Efficacy of Targeting the Contact Pathway to Prevent Device Associated Thrombosis.R01HL151367 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI SHATZEL, JOSEPH JAMES · 2020 to 2024
$1.5M
NHLBI NIH HHS R01 HL151367
6 · The paper itself

Abstract

Background: Venous thromboses are well-established complications of hormonal therapy. Thrombosis risk is seen with both hormonal contraceptive agents and with hormone replacement therapy for menopause and gender transition. Over the past several decades, large epidemiological studies have helped better define these risks. Objectives: To review and discuss the differences in thrombosis risk of the many of hormonal preparations available as well as their interaction with patient-specific factors. Methods: We conducted a narrative review of the available literature regarding venous thrombosis and hormonal therapies including for contraception, menopausal symptoms, and gender transition. Results: Thrombosis risk with estrogen-containing compounds increases with increasing systemic dose of estrogen. While progesterone-only-containing products are not associated with thrombosis, when paired with estrogen in combined oral contraceptives, the formulation of progesterone does impact the risk. These components, along with patient-specific factors, may influence the choice of hormonal preparation. For patients who develop thrombosis on hormonal treatment, anticoagulation is protective against future thrombosis. Duration of anticoagulation is dependent on ongoing and future hormone therapy choice. Finally, the optimal management of hormone therapy for individuals diagnosed with prothrombotic illnesses such as COVID-19 remains unclear. Conclusions: When contemplating hormonal contraception or hormone replacement therapy, clinicians must consider a variety of factors including hormone type, dose, route, personal and family history of thrombosis, and other prothrombotic risk factors to make informed, personalized decisions regarding the risk of venous thrombosis.

Indexed as

estrogenshormonal contraceptionhormone replacement therapythrombosis, transgender people

Identifiers

PMID36032216
PMCPMC9399360
OpenAlexW4293162946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.