Evidence map›Paper›PMID 36032169›Full record

ArticleFrontiers in immunology2022

Enhanced immunogenicity of a positively supercharged archaeon thioredoxin scaffold as a cell-penetrating antigen carrier for peptide vaccines.

Davide Cavazzini, Gloria Spagnoli, Filipe Colaco Mariz, Filippo Reggiani, Stefano Maggi, Valentina Franceschi, Gaetano Donofrio, Martin Müller, Angelo Bolchi, Simone Ottonello

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Davide CavazziniDepartment of Chemistry, Life Sciences & Environmental Sustainability, University of Parma, Parma, Italy.
Gloria SpagnoliDepartment of Chemistry, Life Sciences & Environmental Sustainability, University of Parma, Parma, Italy.
Filipe Colaco MarizGerman Cancer Research Center (DKFZ), Tumorvirus-specific Vaccination Strategies (F035), Heidelberg, Germany.
Filippo ReggianiDepartment of Chemistry, Life Sciences & Environmental Sustainability, University of Parma, Parma, Italy.
Stefano MaggiDepartment of Chemistry, Life Sciences & Environmental Sustainability, University of Parma, Parma, Italy.
Valentina FranceschiDepartment of Veterinary Science, University of Parma, Parma, Italy.
Gaetano DonofrioDepartment of Veterinary Science, University of Parma, Parma, Italy.
Martin MüllerGerman Cancer Research Center (DKFZ), Tumorvirus-specific Vaccination Strategies (F035), Heidelberg, Germany.
Angelo BolchiDepartment of Chemistry, Life Sciences & Environmental Sustainability, University of Parma, Parma, Italy.
Simone OttonelloDepartment of Chemistry, Life Sciences & Environmental Sustainability, University of Parma, Parma, Italy.
University of Parma · ITHeidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycationic resurfaced proteins hold great promise as cell-penetrating bioreagents but their use as carriers for the intracellular delivery of peptide immuno-epitopes has not thus far been explored. Here, we report on the construction and functional characterization of a positively supercharged derivative of

Indexed as

ArchaeaCell-Penetrating PeptidesThioredoxinsAntigensEpitopes, B-LymphocyteHeLa CellsHumansPeptidesVaccines, SubunitAntigensCell-Penetrating PeptidesEpitopes, B-LymphocytePeptidesThioredoxinsVaccines, Subunitantigen carrierepitope displayintracellular antigen deliverypeptide epitopeprotein DNA interactionprotein scaffold engineeringprotein scaffold vaccinerecombinant vaccine

Identifiers

PMID36032169
PMCPMC9405434
OpenAlexW4292452350

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.