ArticleFrontiers in immunology2022
Antibiotic-induced alternations in gut microflora are associated with the suppression of immune-related pathways in grass carp (
Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 40 citations in OpenAlex.
- Article
- Temperature modulates gut microbiome disruption and resistome enrichment in oxytetracycline-treated channel catfish (Microbiology spectrum · 2026Article
- Increased pathogens and reduced intestinal immune genes associated with fish diseases during the winter-spring transition.International microbiology : the official journal of the Spanish Society for Microbiology · 2025Article
- Gut microbiome profiling of antibiotic-treated Mystus cavasius using culture-based and shotgun metagenomic approaches.Antonie van Leeuwenhoek · 2025Article
- Influence of host phylogeny and water physicochemistry on microbial assemblages of the fish skin microbiome.FEMS microbiology ecology · 2024Article
- Persistent Dysbiosis, Parasite Rise and Growth Impairment in Aquacultured European Seabass after Oxytetracycline Treatment.Microorganisms · 2023Article
- Comparative analysis of intestinal microbiota composition and transcriptome in diploid and triploid Carassius auratus.BMC microbiology · 2023Article
- β-Lactam Dosing in Critical Patients: A Narrative Review of Optimal Efficacy and the Prevention of Resistance and Toxicity.Antibiotics (Basel, Switzerland) · 2022Review
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8 authors at 1 institution in 1 country.
Funding
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Abstract
Gut microbiota play a vital role in fish health homeostasis. Antibiotics are known to alter microbial community composition and diversity; however, the substantial effects of antibiotics upon the gut microbiome with respect to immune-related pathways in healthy fish remain unclear. Accordingly, here we explored the impact of two antibiotics on the intestinal health, immune response, microbiome dynamics, and transcriptome profiles of grass carp. A two-week feeding trial was carried out in which the basal diet was complemented with enrofloxacin (10 mg/kg) or florfenicol (10 mg/kg). The results showed that: (1) Enrofloxacin and florfenicol both induced intestinal oxidative stress and reduced the digestive enzyme activity of grass carp. (2) High-throughput sequencing of 16S rDNA revealed that enrofloxacin but not the florfenicol treatment influenced gut microbiota diversity in grass carp by shifting α/β-diversity with more abundant pathogens detected. (3) Transcriptome profiling demonstrated that florfenicol down-regulated the immune-related pathways of grass carp, and the network analysis revealed that IgA was negatively correlated with certain pathogens, such as
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