Evidence map›Paper›PMID 36032100›Full record

ArticleFrontiers in immunology2022

Contribution of pathogenic T helper 1 and 17 cells to bursitis and tenosynovitis in polymyalgia rheumatica.

Rosanne D Reitsema, William F Jiemy, Lieske Wekema, Annemieke M H Boots, Peter Heeringa, Minke G Huitema, Wayel H Abdulahad, Yannick van Sleen, Maria Sandovici, Caroline Roozendaal and 5 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. The Immune Checkpoint Inhibitors Journey: From Early Promise to Lasting Impact.Journal of immunotherapy and precision oncology · 2026
    Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Observational
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Rosanne D ReitsemaDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
William F JiemyDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Lieske WekemaDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Annemieke M H BootsDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Peter HeeringaDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Minke G HuitemaDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Wayel H AbdulahadDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Yannick van SleenDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Maria SandoviciDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Caroline RoozendaalDepartment of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Arjan DiepstraDepartment of Pathology and Medical Biology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Thomas KweeMedical Imaging Center, Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Bhaskar DasguptaDepartment of Rheumatology, Southend University Hospital, Westcliff-on-Sea, United Kingdom.
Elisabeth BrouwerDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
Kornelis S M van der GeestDepartment of Rheumatology and Clinical Immunology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands.
University Medical Center Groningen · NLUniversity of Groningen · NLSouthend University Hospital NHS Foundation Trust · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Although polymyalgia rheumatica (PMR) is a very common rheumatic inflammatory disease, current insight into the pathobiology of PMR is limited and largely based on studies in blood. We investigated T helper 1 (T Materials and methods: Blood samples were collected from 18 patients with new-onset PMR and 32 healthy controls. Synovial fluid was aspirated from the inflamed shoulder bursae or biceps tendon sheath of 13 patients. Ultrasound-guided biopsies of the subacromial-subdeltoid (SASD) bursa were obtained from 11 patients. T cells were examined by flow cytometry, immunohistochemistry and immunofluorescence staining. Results: Besides an increase of T Conclusion: Although the circulating T

Indexed as

BursitisGiant Cell ArteritisPolymyalgia RheumaticaTenosynovitisCD8-Positive T-LymphocytesHumanspolymyalgia rheumaticaT cellsT helper 1T helper 17ultrasound guided biopsy

Identifiers

PMID36032100
PMCPMC9402989
OpenAlexW4291003355

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.