ArticleAmerican journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons2022
Prognostic implications of and clinical risk factors for acute lung injury and organizing pneumonia after lung transplantation: Data from a multicenter prospective cohort study.
Article in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Identical versus compatible blood typing: investigating best practices in lung transplantation.Transplant international : official journal of the European Society for Organ Transplantation · 2026Article
- Sustained Molecular Allograft Injury After Episodes of Acute Rejection and Organizing Pneumonia Increases the Risk of Lung Allograft Failure.Transplantation direct · 2025Article
- Basiliximab induction immunosuppression and lung transplant outcomes: Propensity analysis in a multicenter cohort.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Identification and validation of a threshold for early posttransplant bronchoalveolar fluid hyaluronan that distinguishes lung recipients at risk for chronic lung allograft dysfunction.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Diagnostic alignment to optimize inter-rater reliability among lung transplant pathologists.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2025Article
- Prognosis and Risks for Probable Chronic Lung Allograft Dysfunction: A Prospective Multicenter Study.American journal of respiratory and critical care medicine · 2025Article
- Organizing pneumonia is associated with molecular allograft injury and the development of antibody-mediated rejection.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2024Article
- BAL Fluid Eosinophilia Associates With Chronic Lung Allograft Dysfunction Risk: A Multicenter Study.Chest · 2023Article
- Early posttransplant reductions in club cell secretory protein associate with future risk for chronic allograft dysfunction in lung recipients: results from a multicenter study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2023Article
- Thoracic Ultrasound in Lung Transplantation-Insights in the Field.Life (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
26 authors at 9 institutions in 2 countries.
Funding
Abstract
We determined prognostic implications of acute lung injury (ALI) and organizing pneumonia (OP), including timing relative to transplantation, in a multicenter lung recipient cohort. We sought to understand clinical risks that contribute to development of ALI/OP. We analyzed prospective, histologic diagnoses of ALI and OP in 4786 lung biopsies from 803 adult lung recipients. Univariable Cox regression was used to evaluate the impact of early (≤90 days) or late (>90 days) posttransplant ALI or OP on risk for chronic lung allograft dysfunction (CLAD) or death/retransplantation. These analyses demonstrated late ALI/OP conferred a two- to threefold increase in the hazards of CLAD or death/retransplantation; there was no association between early ALI/OP and these outcomes. To determine risk factors for late ALI/OP, we used univariable Cox models considering donor/recipient characteristics and posttransplant events as candidate risks. Grade 3 primary graft dysfunction, higher degree of donor/recipient human leukocyte antigen mismatch, bacterial or viral respiratory infection, and an early ALI/OP event were significantly associated with increased late ALI/OP risk. These data from a contemporary, multicenter cohort underscore the prognostic implications of ALI/OP on lung recipient outcomes, clarify the importance of the timing of these events, and identify clinical risks to target for ALI/OP prevention.
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