Evidence map›Paper›PMID 36031315›Full record

ReviewHandbook of clinical neurology2022

Apnea of prematurity and sudden infant death syndrome.

Richard J Martin, Lisa J Mitchell, Peter M MacFarlane

Abstract readReview
In one paragraph

Review in Handbook of clinical neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Reducing the risk of sudden unexpected infant death: the caffeine hypothesis.Journal of perinatology : official journal of the California Perinatal Association · 2025
    Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Richard J MartinDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, United States. Electronic address: rxm6@case.edu.
Lisa J MitchellDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, United States.
Peter M MacFarlaneDivision of Neonatology, Department of Pediatrics, Rainbow Babies & Children's Hospital, Case Western Reserve University, Cleveland, OH, United States.

Funding

NEURAL REGULATION OF AIRWAYS DURING POSTNATAL MATURATIONR01HL056470 · NHLBI · MAYO CLINIC ROCHESTER · PI PRAKASH, Y. S. · 1996 to 2025
$10.5M
Understanding CPAP Effects in the Developing AirwayR01HL138402 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI MACFARLANE, PETER · 2017 to 2020
$2.5M
NHLBI NIH HHS R01 HL056470NHLBI NIH HHS R01 HL138402
6 · The paper itself

Abstract

Apnea is a frequent occurrence in prematurity and its prevalence in the most severely preterm population is indicative of an immature respiratory neural control system. Preterm infants are also at increased risk of Sudden Infant Death Syndrome (SIDS), which has been associated with similar respiratory neural control dysfunction seen in prematurity. Generally, abnormalities in both central and peripheral mechanisms of respiratory control are thought to be key underlying features of abnormal respiratory system development. Numerous factors contribute to the etiology of apnea and respiratory control dysfunction including the environment (e.g., substance use/misuse), sex, genetics, a vulnerable neonate, and various underlying comorbidities. However, there are major gaps in our understanding of both normal and abnormal respiratory control system development, which highlights the need for continued research using novel and innovative methods.

Indexed as

Infant, Premature, DiseasesSudden Infant DeathApneaHumansInfantInfant, NewbornInfant, PrematureApneaBrainstemCarotid bodyIntermittent hypoxemiaPrematuritySIDS

Identifiers

PMID36031315
PMCPMC11472323

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.