Evidence map›Paper›PMID 36030799›Full record

Observational studyThe lancet. Diabetes & endocrinology2022

Association between fetal abdominal growth trajectories, maternal metabolite signatures early in pregnancy, and childhood growth and adiposity: prospective observational multinational INTERBIO-21st fetal study.

Jose Villar, Roseline Ochieng, Robert B Gunier, Aris T Papageorghiou, Stephen Rauch, Rose McGready, Julia M Gauglitz, Fernando C Barros, Manu Vatish, Michelle Fernandes and 19 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The lancet. Diabetes & endocrinology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 2 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 39 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Beyond Deterministic Fetal Programming: Intrauterine Exposures and the Multifactorial Origins of Adiposity.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
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  11. Effect of Gestational Diabetes on Fetal Growth Rate and Later Overweight in the Offspring.The Journal of clinical endocrinology and metabolism · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

29 authors at 16 institutions in 9 countries.

Jose VillarNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK. Electronic address: jose.villar@wrh.ox.ac.uk.
Roseline OchiengFaculty of Health Sciences, Aga Khan University, Nairobi, Kenya.
Robert B GunierCenter for Environmental Research and Community Health, School of Public Health, University of California, Berkeley, CA, USA.
Aris T PapageorghiouNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.
Stephen RauchCenter for Environmental Research and Community Health, School of Public Health, University of California, Berkeley, CA, USA.
Rose McGreadyCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Julia M GauglitzSapient Bioanalytics, San Diego, CA, USA.
Fernando C BarrosPrograma de Pós-Graduação em Saúde e Comportamento, Universidade Católica de Pelotas, Pelotas, Brazil.
Manu VatishNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Wellcome Centre for Human Genetics, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
Michelle FernandesNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Medical Research Council Lifecourse Epidemiology Centre & Human Development and Health Academic Unit, Faculty of Medicine, University of Southampton, Southampton, UK.
Victor ZammitBiomedical Sciences, Translational & Experimental Medicine, Warwick Medical School, University of Warwick, Coventry, UK.
Verena I CarraraCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Shama MunimDepartment of Obstetrics and Gynaecology, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan.
Rachel CraikNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Hellen C BarsosioKenya Medical Research Institute-Coast Centre for Geographical Medicine and Research, University of Oxford, Kilifi, Kenya.
Maria CarvalhoDepartment of Obstetrics & Gynaecology, Faculty of Health Sciences, Aga Khan University Hospital, Nairobi, Kenya.
James A BerkleyCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Kenya Medical Research Institute-Coast Centre for Geographical Medicine and Research, University of Oxford, Kilifi, Kenya.
Leila I Cheikh IsmailNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Clinical Nutrition and Dietetics Department, University of Sharjah, Sharjah, United Arab Emirates.
Shane A NorrisSouth African Medical Research Institute Developmental Pathways For Health Research Unit, Department of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa.
Chrystelle O O Tshivuila-MatalaNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; South African Medical Research Institute Developmental Pathways For Health Research Unit, Department of Paediatrics & Child Health, University of the Witwatersrand, Johannesburg, South Africa; Health, Nutrition & Population Global Practice, World Bank Group, Washington, DC, USA.
Francois NostenCentre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand.
Eric O OhumaNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Maternal, Adolescent, Reproductive & Child Health Centre, London School of Hygiene & Tropical Medicine, London, UK.
Alan SteinDepartment of Psychiatry, University of Oxford, Oxford, UK; Medical Research Council and Wits Rural Public Health and Health Transitions Research Unit (Agincourt), School of Public Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; African Health Research Institute, KwaZulu-Natal, South Africa.
Ann LambertNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.
Adele WinseyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK.
Ricardo UauyDepartment of Nutrition and Public Health Interventions Research, London School of Hygiene and Tropical Medicine, London, UK.
Brenda EskenaziCenter for Environmental Research and Community Health, School of Public Health, University of California, Berkeley, CA, USA.
Zulfiqar A BhuttaCentre of Excellence in Women and Child Health, Aga Khan University, Nairobi, Kenya; Center for Global Child Health, Hospital for Sick Children, Toronto, ON, Canada.
Stephen H KennedyNuffield Department of Women's & Reproductive Health, University of Oxford, Oxford, UK; Oxford Maternal & Perinatal Health Institute, Green Templeton College, University of Oxford, Oxford, UK.
University of Oxford · GBUniversity of California, Berkeley · USAga Khan University Nairobi · KELondon School of Hygiene & Tropical Medicine · GBMahidol Oxford Tropical Medicine Research Unit · THAfrica Health Research Institute · ZAAga Khan University · PKAga Khan University Hospital Nairobi · KEKenya Medical Research Institute · KEMRC Lifecourse Epidemiology Unit · GBShoklo Malaria Research Unit · THSouth African Institute for Medical Research · ZAUniversidade Católica de Pelotas · BRUniversity of Sharjah · AEUniversity of Warwick · GBWorld Bank Group · US

Funding

Medical Research Council MR/V029169/1
6 · The paper itself

Abstract

backgroundObesity predominantly affects populations in high-income countries and those countries facing epidemiological transition. The risk of childhood obesity is increased among infants who had overweight or obesity at birth, but in low-resource settings one in five infants are born small for gestational age. We aimed to study the relationships between: (1) maternal metabolite signatures; (2) fetal abdominal growth; and (3) postnatal growth, adiposity, and neurodevelopment.

methodsIn the prospective, multinational, observational INTERBIO-21st fetal study, conducted in maternity units in Pelotas (Brazil), Nairobi (Kenya), Karachi (Pakistan), Soweto (South Africa), Mae Sot (Thailand), and Oxford (UK), we enrolled women (≥18 years, with a BMI of less than 35 kg/m

findingsFrom Feb 8, 2012, to Nov 30, 2019, we enrolled 3598 pregnant women and followed up their infants to 2 years of age. We identified four ultrasound-derived trajectories of fetal abdominal circumference growth that accelerated or decelerated within a crucial 20-25 week gestational age window: faltering growth, early accelerating growth, late accelerating growth, and median growth tracking. These distinct phenotypes had matching feto-placental blood flow patterns throughout pregnancy, and different growth, adiposity, vision, and neurodevelopment outcomes in early childhood. There were 709 maternal metabolites with positive effect for the faltering growth phenotype and 54 for the early accelerating growth phenotype; 31 maternal metabolites had a negative effect for the faltering growth phenotype and 76 for the early accelerating growth phenotype. Metabolites associated with the faltering growth phenotype had statistically significant odds ratios close to 1·5 (ie, suggesting upregulation of metabolic pathways of impaired fetal growth). The metabolites had a reciprocal relationship with the early accelerating growth phenotype, with statistically significant odds ratios close to 0.6 (ie, suggesting downregulation of fetal growth acceleration). The maternal metabolite signatures included 5-hydroxy-eicosatetraenoic acid, and 11 phosphatidylcholines linked to oxylipin or saturated fatty acid sidechains. The fungicide, chlorothalonil, was highly abundant in the early accelerating growth phenotype group.

interpretationEarly pregnancy lipid biology associated with fetal abdominal growth trajectories is an indicator of patterns of growth, adiposity, vision, and neurodevelopment up to the age of 2 years. Our findings could contribute to the earlier identification of infants at risk of obesity.

fundingBill & Melinda Gates Foundation.

Indexed as

Fungicides, IndustrialPediatric ObesityAdiposityFemaleFetal DevelopmentHumansKenyaOxylipinsPhosphatidylcholinesPlacentaPregnancyPrenatal CareProspective StudiesSouth AfricaUltrasonography, PrenatalFungicides, IndustrialOxylipinsPhosphatidylcholines

Identifiers

PMID36030799
PMCPMC9622423
OpenAlexW4293123356

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.